维生素K对幼鼠骨量及骨强度影响的试验研究-中国骨质疏松杂志.PDF

CHINESEJOURNALOFOSTEOPOROS1SVot．5No．11999 维生素K对幼鼠骨量及骨强度影响的实验研究 赵新华 赵熙和 崔伟 任典旭 摘要 目的 从骨计量学及骨生物力学等方面评价维生素K对幼鼠骨 发育的影响 结果 股骨及腰椎骨计量学各参数值(骨湿重、干重、骨体积、骨 密度、骨小粱面积等)随维生翥K摄入水平增加而增加；腰椎各计量学参数值 在饲料维生索K水平超过300Fg／kg时，无显著变化；维生索K可提高股骨的 结构力学性能(最大载荷与结构硬度)．而对其材料力学性能无显著影响。结论 维生素K能促进幼鼠骨发育；从骨健康角度考虑，目前根据凝血功能需求建 议的大鼠饲料维生素K需要量(即本实验低剂量组：50~g／kg饲料)不能满足 幼鼠骨发育需求 关键调 维生素K 骨计量学 骨生物力学 EffectofvariouslevelsofvitaminK intakeolnparametersofbonemetrologyandhiomechanJcsinrats ZhaoXinhua，ZhaoXihe．CuiWe1．etaI Departmentofbiochemistry，BeijingJiShuiTanHospiatl，Beijing100035，China A~traet Objective ToexploretheeffectofvariouslevelsorvitaminKintakeonbonedevelop- ment—MethodsFortyweanlingWistarmaleratswe dividedintofourgroups．Inonegroup．1 sulfadi— azlnewasaddde toregulardiet(vitaminK5O ／kg)toinducevitaminKdeficiencyIntheotherthree groups，thevitaminKlevelindietswere50·300and2550 ／kgrespectively．Twelveweekslater．the ratswe killedandeffectsofthe differentlevelofvitaminK intakeonbonedevelopmentwereeva[uat— tdbytheparametersofbonemetrologyandbonebiomechanics． Results Femurmetrologicalparame一 ”e8(boneweight，bonevolume，bohemineraldensityandare8softrahecularhoneetc improvde with theincreaseofdietaryvitaminKleve1．whiletheparametresoflumbarspinedidnotchangewhenvita— rainK levelwasover300Pg／kgdiet·vitaminK couldimprovethefemoralstructuralbiomechanical propertles(strengthandrigidity)．buthadnoeffectonthematerialbiomechanicalproperties Condu- sion VitaminK cBnenhancethedevelopmentofbone．The ratvitaminK requirementmayhe higher thanthatcurrentlyrecommendde(50腿 ／kgdiet)． Keywords VitaminK Bonemetrology Bo nebiomecbardcs