黄芪多糖(APS)对严重烫伤兔心功能损害的保护作用-外科学(烧伤)专业毕业论文.docxVIP

PAGE PAGE IV 摘要 1 天升高到达峰值，继而逐渐下降，至伤后 14 天恢复正常；CT-1 值，两组兔伤 后 1、3、7 天均升高(P?0.05)，而伤后 14 天无差异。 APS 组与 Model 组比较： 伤后各时相点，APS 组 Ang II、CT-1 值均明显低于 Model 组，差异均有显著性 (P?0．05)。 7、血液流变学（ηb、ηr、ηp、HCT、ESR、EAI、TK）变化 与伤前比较：ηr、ηp、HCT、ESR、EAI、TK 值和各切变率下的ηb 值， Model 组伤后 1、3、7d 均升高 (P0．05)，14 天恢复正常，APS 组伤后 1、3 天升高(P0．05)，而伤后 7、14 天恢复正常；APS 组与 Model 组比较：上述各 血液流变学指标值，APS 组伤后 1、3、7 天均较 Model 组低，存在显著性差异(P0． 05)，伤后 14 天无差异。 结论： 1、严重烫伤兔心肌损伤标志物、氧化-抗氧化性能、缩血管活性物质、血液 流变学等心功能相关指标及心肌病理均有不同程度的异常改变，表明严重烫伤 对兔心脏功能产生了不同程度的损害。 2、黄芪多糖早期干预后，烫伤兔心肌损伤标志物、氧化-抗氧化性能、缩血 管活性物质、血液流变学等心功能相关指标及心肌病理均有不同程度的恢复， 表明黄芪多糖可减轻严重烫伤对兔心肌细胞的损害，对烧伤早期心功能起到了 较好的保护作用。 关键词：黄芪多糖（APS）；严重烫伤；兔；心肌损伤标志物；氧化-抗氧化性能； 缩血管活性物质；血液流变学指标；心肌病理改变；保护作用 Ab Abstract PAGE PAGE V ABSTRACT Objective： 1．Establishment of acute bum rabbit model， study the lesion of cardiac function in severely scald rabbit.and observe the change rule of the biomarks of myocardial injury(aspartate aminotransferase--AST,Creat-ine kinase--CK,creatine kinase--CK-MB, lactate Dehydrogenase--LDH, Troponin I--cTnI),Oxidation-antioxi -dation property (malondialdehyde--MDA, superoxide dismutase--SOD), active va soconstrictors(Angiotensin II--Ang II, Endothelin-1--CT-1),hemorheological index es as well as myocardial pathology. 2．To study the protective effect of astragalus polysaccharides on Cardiac dysfunction in severely scalded rabbit which was early intervened by APS via investigating the changes of the biomarkers of myocardial Injury (AST, CK, CK -MB, LDH, cTnI), oxidation-antioxidation property (MDA, SOD), active vasocon strictors(Ang II, CT-1), hemorheological indexes and myocardial pathology. Methods： 64 healthy adult male rabbits were choosed as a subject of the study,which were wighted (2.4 ± 0.2) kg .The rabbits were randomly divided into two groups: Simple burn group(called Model group), scald with astragalus polysaccharide treatment group(called APS group), with 32 rabbits in each group. The rabbits were allowed to acclimate for 1 week, handpicked four rabbits fro