环境中磺胺类药物的残留、形态转化及生态毒性研究-环境工程专业论文.docxVIP

ABSTRACTSulonamides ABSTRACT Sulonamides synthetic antimicrobial agents，which used in aquaculture，animal husbandry,and also human medicines to treat many kinds of infection caused by bacteria and certain other microorganisms．Because sulfonamide antibiotics usually cannot be absorbed completely in the gut of the animals，a large proportion of parent compounds acetylated metabolites have been excreted into environment through faeces and urine．As result，sulfonamides were usually detected in the environment． Manure，soil and vegetable samples were collected from 13 different livestock farms ofdifferent sizes in Xinxiang of China,and the residues of three sutfonamides including sulfadiazine，sulfamonomethoxine， and sulfamethoxazole were analyzed by HPLC with fluorimetric detector．The results indicated that the concentration ranges ofthe three total sulfonamides in manure，soil and vegetable WaS 10．13．566．231xg·kg-1， 7．60-176．2699·kg～and ND-32．7099·埏～，respectively．The mean concentrations were 219．71lag-kg～， 70．7399·kg-1 and 7．08p．g·蟮1 for manure，soil and vegetables，respectively．The mean concentrations in soft were lower than the ecotoxic effect trigger value(1 00pg·kg1)set by the Veterinary Medicine Intemafional Coordination Commission，indicating the low risk for organisms in soil。The concentrations of three sulfonamides varied significantly in different kinds of vegetables and all were lower than the acceptable daily intake values(50pg-(kg·dyl)set by Joint FAO／WHO Expert Committee Food Additives．But we cazmot neglect the potential ecotoxicity and resistance for human via food chain． Form transformation and degradation of sulfadiazine and sulfamethoxazole were studied in artificial root exudates-soils and control—soil using batch approach．The results indicated that the percentages of organic solvent extractable，water soluble and bound residues were 86．5-98．5％，0．6—7．3％and 0．1-12．5％of the total residues,respectively．The o唱anic solvent extractable residues were the main form in