【精品课件教案ppt】 紫杉醇释放ptca球囊导管治疗冠状动脉疾病.ppt

mm pre PCI vs. 9 month: p 0,001 p = 0,038 Late Loss 0,38 mm x Late Loss x 0,21 mm * PEPCAD V研究 30 day follow up MACE 0/28 (0%) 9 month follow up Death 0/28 (0%) Late Stent Thrombosis(1x definite, 1x probable) 2/28 (7,1%) Restenosis with TLR 1/28 (3,6%) Restenosis without TLR 2/28 (7,1%) * PEPCAD V研究 SeQuent Please World Wide: A Large-Scale Registry Study of a Paclitaxel Coated BalloonSeQuent Please 紫杉醇洗脱球囊全球大规模登记研究 Prof. Dr. Jochen W?hrle University of Ulm Ulm, Germany SeQuent Please World Wide Registry 研究目的与方法 评估紫杉醇洗脱球囊-SeQuent Please 治疗所有可能适应征的有效性和安全性 国际多中心真实世界中的登记研究 主要研究终点 clinically driven TLR @ 9 months 次要研究终点 MACE @ 9 and 24 months MACE事件 = cardiac death, MI due to target vessel, ischemia driven TLR 9个月和24个月临床随访 SeQuent Please World Wide Registry Patients Germany 1452 South Africa 158 Spain 143 France 142 Pakistan 97 Malaysia 50 Czech Republic 38 Switzerland 15 2095 patients SeQuent Please World Wide Registry 患者入选分布 Number of patients 2095 Number of lesions 2348 Male 74.1% Diabetes Mellitus 36.0% History of smoking 41.6% Hyperlipidemia 74.5% Hypertension 85.7% Dialysis 6.3% ACS 16.9% 基线分布 SeQuent Please World Wide Registry Patients Lesions SeQuent Please WWR 2095 2348 ISR BMS 730 807 ISR DES 457 492 De-novo with DEB only 388 476 ACS 355 373 STEMI 90 94 Diabetes mellitus 754 802 病变分布 SeQuent Please World Wide Registry Mean follow-up 9.4 months 结果 SeQuent Please World Wide Registry MACE = cardiac death, MI due to target vessel, ischemia driven TLR p 0.001 Mean follow-up 9.1 months 结果 p 0.001 p = 0.002 p = 0.029 p = 0.566 SeQuent Please World Wide Registry MACE = cardiac death, MI due to target vessel, ischemia driven TLR p = 0.010 Mean follow-up 9.4 months 结果 p = 0.096 p = 0.211 p = 0.04 p = 0.04 SeQuent Please World Wide Registry MACE = cardiac death, MI due to target vessel, ischemia driven TLR 小结 SeQuent Please World Wide Registry 研究 是药物洗脱球囊迄今为止最大规模的登记研究，包括DES or BMS restenosis, 原发病变de-novo lesions 和 ACS 患者. 在总研究群体中缺血驱动的 TLR发生率较低.