急性冠脉综合征患者血清可溶性E-选择素和白介素-10水平的变化及其与冠脉病变程度的相关性-内科学(心血管病)专业论文.docxVIP

4 4 安徽医科大学硕士学位论文 Materials and Methods: Total 94 patients who were suspected suffering from CHD and received coronary angiography(CAG) were selected for the study. 32 patients with normal CAG as controls; 62 patients had angiographic stenosis of coronary arteries, including 23 patients with SAP, 39 patients with ACS. Serum SES、IL-10 level was determined by ELISA and the stenosis with ≥25% diameter reduction were assessed according to angiographic coronary stenosis morphology. Results:（1）The serum levels of SES in ACS group（2.11±0.13ng/ml） were significantly higher than those in SAP group and control group（1.37±0.16,1.42±0.14 ng/ml）（all P0.01）, which were similar in SAP group and control group（P0.05）; the serum levels of IL-10 in ACS group（402.87±19.21pg/ml） were higher than those in SAP group and control group（330.52±25.01,300.47±21.20 pg/ml）（P0.05, P0.01）; The serum levels of hs-CRP were highest in ACS group（773.33±50.49ug/dl）（all p0.01）; The serum levels of SES、IL-10、hs-CRP were similar among SAP and control groups（P0.05）;（2）The serum levels of SES had statistical relationship with hs-CRP levels (P0.05,r=0.260）; The serum levels of IL-10 had no statistical relationship with hs-CRP level（s P0.05,r=0.098）; (3) There were no statistical relationship in SES、IL-10 and hs-CRP levels with the count of coronary artrey stenosis (r = 0.093、-0.026、0.056) （all P0.05）and the degree of coronary artery stenosis(r = 0.043、-0.077、0.051)（all P0.05）. Conclusions:（1） The serum levels of SES、IL-10 were significantly elevated in ACS. It exposed they may reflected the intability of atherosclerotic plaques ; The serum levels of SES and IL-10 may be a valuable target to predict unstable plaques as well as coronary heart risk;（2）They cannot reflected the degree of coronary artery stenosis . KEY WORDS: Acute coronary syndrome(ACS)/Soluble E-selectin(SES) /Interleukin-10(IL-10) 英文缩略语表 缩略语 英文全称 中文全称 ACS acute coronary syndrome 急性冠脉综合征 AMI acute myocardial infarcti