急性冠脉综合征患者血清可溶性E 选择素和白介素 10水平的变化及其与冠脉病变程度的相关性-内科学(心血管病)专业论文.docxVIP

安徽医科大学硕士学位论文 安徽医科大学硕士学位论文 PAGE PAGE 2 （P0.05）；血清IL-10水平ACS 组（402.87±19.21pg/ml）显著高于SAP组和对照组 （330.52±25.01、300.47±21.20 pg/ml）（P0.05, P0.01），而SAP组和对照组之间无 显著性差异（P0.05）；血清hs-CRP水平ACS组（773.33±50.49ug/dl）显著高于SAP 组和对照组（399.96±65.75、231.75±55.74 ug/dl）（均P0.01），SAP组和对照组之 间无显著性差异（P0.05）；（2）ACS组血清SES水平与hs-CRP水平呈正相关 (P0.05,r=0.260），IL-10水平与hs-CRP水平无相关性（P0.05, r=0.098）；(3) ACS 组及SAP组血清SES 、IL-10、hs-CRP水平与病变支数均无相关性（r=0.093、-0.026、 0.056, 均P0.05），与Gensini积分也均无相关性（r=0.043、-0.077、0.051，均P0.05）。 结论 （1）ACS 患者血清 SES、IL-10 水平明显升高，提示血清中 SES、IL-10、 增高可能与斑块的不稳定有关，SES、IL-10 可以作为检测不稳定斑块以及冠心病 危险分层的一种有价值的指标。（2）SES、IL-10 水平的高低与冠脉病变狭窄程度 之间无明显相关性。 【关键词】 急性冠脉综合征 可溶性 E-选择素 白介素-10 Correlation between soluble E- selectin、Interleukin-10 and the degree of coronary artery lesions in acute coronary syndrome Abstract Background: Acute coronary syndrome (ACS) is a group of serious cardiovascular diseases, including unstable angina(UA), non-ST segment elevation myocardial infartion(NSTEMI) 、ST-segment elevation myocardial infartion(STEMI) and sudden death. Atherosclerotic plaques unstable、rupture、resultant platelet aggregation and thrombus formation causing acute coronary artery obstruction or coronary artery luminal stenosis increased dramatically is believed to be responsible for most of the development. In the process, inflammation is the most important initiating factor. Both inflammatory factors and anti-inflammatory factors are joining in the pathophysiological process. Recently, it has been demonstrated that the serum levels of soluble E-selectin(SES) in ACS patients are significantly higher than those in normal patients, and the serum levels of soluble Interleukin-10(IL-10) are also significant changed in ACS patients. It is prompted that the serum levels of inflammatory factor SES and anti-inflammatory factor IL-10 might correlated with the development of coronary heart disease(CHD) and the instability of plaque, it migh be a sensitive marker to predict the outcome of CHD. Objective: To