乳香大环二萜类化学成分研究MacrocyclicDiterpenesfromBoswellia.PDF

2010 年第 30 卷 有 机 化 学 Vol. 30, 2010 第 1 期, 107～111 Chinese Journal of Organic Chemistry No. 1, 107～111 ·研究简报· 乳香大环二萜类化学成分研究 李福双 a 徐康平 a 袁寿洪 b 颜冬兰 a 刘让如 a 谭健兵 a 曾光尧 a 周应军 a 谭桂山*,a,b (a 中南大学药学院 长沙 410013) (b 中南大学湘雅医院药剂科 长沙 410008) 摘要 采用硅胶柱层析, 制备薄层层析等色谱方 , 从乳香 CO2 超临界提取物中分得 7 个大环二萜类化合物, 经波谱方 法鉴定为 incensole acetate (1), incensole (2), incensole oxide acetate (3), isoincensole acetate (4), incensole oxide (5), isoin- censole oxide (6), isoincensolol (7), 其中, 化合物 7 为新化合物, 化合物 4 为首次从该属植物中分离得到. 采用四甲基偶 氮唑蓝(MTT)法观察化合物对肿瘤细胞的抑制增殖作用. 关键词 乳香; 化学成分; 大环二萜; 抗肿瘤; isoincensoleol Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense) Li, Fushuanga Xu, Kangpinga Yuan, Shouhongb Yan, Donglana Liu, Rangrua Tan, Jianbinga Zeng, Guangyaoa Zhou, Yingjuna Tan, Guishan*,a,b a ( School of Pharmaceutical Sciences, Central South University, Changsha 410013) (b Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008) Abstract Seven macrocyclic diterpene compounds were isolated from Boswellia carterii Birdwood (Frankincense) and purified by silica-gel column chromatorgraphy and preparative thin-layer chromatogra- phy (TLC). Their structures were elucidated as incensole acetate (1), incensole (2), incensole oxide acetate (3), isoincensole ac