热疗在消化 道肿瘤综合治疗中的地位课件整理.pptxVIP

热疗在消化道肿瘤综合治疗中的地位;;;消化道肿瘤治疗主要手段;肿瘤热疗发展了500年——走向精准;温度场磁共振成像;Pennes Bioheat Equation（潘尼斯生物热物理公式） ;美国Pyrexar公司的BSD3000;美国 INSIGHTEC公司磁共振引导下的HIFU;热疗联合放疗;热疗联合化疗;热疗联合放化疗;;;;;化疗联合热疗治疗食管癌的Meta 分析;Study Design ;primary tumor response: 31 (39.7%) exhibited a complete response (CR) of the primary lesions, 43 (56.4%) exhibited a partial response (PR) and 3 (3.9%) cases exhibited stable disease (SD). The total response rate (CR + PR) of the primary tumor to the trimodal treatment was as high as 96.1%.;小结;;图像引导下的热消融;MR引导下的HIFU消融;;;;结果：;119例不能手术切除肝转移结直肠癌患者;结果;结论;;腹腔热灌注化疗简史;腹腔热灌注化疗的药物选择;腹腔热灌注化疗的药物选择;;腹膜恶性肿瘤行肿瘤细胞减灭术联合腹腔热灌注化疗的疗???;;;;;;结论;Tristan D A Systematic Review and Meta-analysis of the Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Gastric Cancer. Annals of Surgical Oncology 2007.14(10):2702–2713;PF 方案联合顺铂腹腔热灌注化疗术后辅助化疗 治疗局部晚期胃癌的临床研究;Results: Clinical data of patients;DFS;;Results: Adverse reactions;小结;;OPTIMA研究;使用纳米热敏脂质体包裹化疗药物，利用温度控制脂质体内药物释放;;;结果;;晚期胃癌腹水中分离的Exosomes加热后诱导肿瘤特异性CTL细胞应答;癌性腹水中高速离心分离出来的Exosomes;Cytokine secretion;CIK细胞腹腔热灌注治疗晚期肝癌;结果：;TTP and OS;;Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines;;结果;;小结;;Thank You For Your Attention!