皇冠苷A的提取及其衍生物的合成-有机化学专业论文.docxVIP

郑州大擘硕士论文行了含量测定，比较乙醇回流和超声提取两种方法；对皇冠苷A进行了初步的 郑州大擘硕士论文 行了含量测定，比较乙醇回流和超声提取两种方法；对皇冠苷A进行了初步的 结构改造；共提取分离和合成化合物17个，其中新化合物10个，他们的结构均 经红外光谱、核磁共振谱、高分辨质谱等鉴定；并对衍生物进行了活性测定。 关键词： 皇冠苷A；芒果素；挥发油；二苯甲酮；结构鉴定；4．氯-4．脱氧廿D- 半乳糖；Koenigs-Knorr反应 II 郜州大学硕士论文 郜州大学硕士论文 Abstract Mahkota Dewa(Phaleria macrocarpa[Scheff．J BoerO was widely distributed in Indonesia,empirically,the stems、leaves and fruits of which Wgfe used to control many diseases such as c{uAcer、impotency、hemorrhoid、diabetes mellitus、allergies、 liver and heart diseases、kidney disorders、blood diseases、rheumatism、high blood presst鹏、stroke、migraine、various skin diseases、agile，and SO forth．In this dissertation,the chemical components of Mahkota Dewa had been investigated systematically．Some derivatives of Mahkoside A were designed and synthesized based 011 the extraction and isolation ofthe plant．The vitro bioaetivity ofthemⅥm sttldies． 1．Five compounds were isohted from the fnhm of Mahkota Dewgl by using various cb舳哦。印m and were elucidated by NM＆腿—MS，Ⅱ～et a1．1k s劬】曲珊1 oftbe compounds wefe：myristic acid、9-sitosterol-3-O—pD-glucoside、Mahkoside A、mangiferm,glucose． 2．To develope a method of extract of the content of Mahkoside A in the seed of Mahkota Dewa．11蟛Mahkoside A was determined by spcctrophotomctry with Mahkoside A standard,using ultrasonicxtractioll and reflux extraction,respectively． n略ullzasonic a【h弼吐on was better than reflux exUl础on and was simple, reproducible and suitable for the出糖棚1ina矗on of Mahkoside A．11b method of isolation of the content of Mahkoside A in the seed of Mahkota Dewa was studies based On the analyses of the chemical components．Mahkoside A was isolated and purified．田地method was simple and had bigh extraclion yield． 3．Mahkoside A was a n跚delivative ofbenzophenone，which often exhibited a wide rallge of biological and pharmacological activities,e．g．，antioxidant,eytotoxic， antiinflammatory,antimicrobial，aatifungal，and inhibitory effects 011 xanthine oxidase and monoamine oxidase．In order to study the struc