肌钙蛋白Ⅰ曲线下面积、B型钠尿肽与PCI术后急性心肌梗死近期预后的关系-心血管内科专业论文.docxVIP

·中文论著摘要·肌钙蛋白I曲线下面积、B型钠尿肽与PCI术后 急性心肌梗死近期预后的关系目的探讨肌钙蛋白I曲线下面积、BNP等指标在ST段抬高心肌梗死患者急诊经皮冠 状动脉介入治疗后30天不良事件的预测价值。方法选择因急性ST段抬高心肌梗死入院的患者，发病内12d,时成功完成经皮冠状 动脉介入(PCI)治疗的患者26例。根据罪犯血管开通距发病时间分为2组：PCI 距发病6h为组1，PCI距发病≥6h为组2。所有入选患者测定发病后6d,时、12d,时、24d时、48d时、72d时肌钙蛋白I(c州)、肌酸激酶同工酶(CK．MB)，分别描绘时间．浓度曲线。发病24d时内完成B型钠尿肽测定，入院10天以内完成超声 心动图左室舒末内径、左室射血分数测定。随访30-a：5天，记录终点事件(心力衰 竭或死亡)。’结果(1)肌钙蛋白曲线下面积与入选病例30天近期预后无相关性，无统计学意义 (p0．05)；同样，肌酸激酶同工酶曲线下面积与预后无相关性(p0．05)；(2)B 型钠尿肽、左室射血分数(LVEF)与预后显著相关，有统计学意义(p0．01)，ROC 曲线显示，BNP和LVEF可以作为预i贝tJSTEMI近期不良事件的指标；(3)B型钠尿肽 与左室射血分数(LVEF)显著相关，有统计学意义(po．01)。结论肌钙蛋白曲线下面积、肌酸激酶同工酶曲线下面积不适合评测STEMI介入治 疗后近期预后；B型钠尿肽、LVEF可用来预测STEMl近期不良事件的发生；在 STEMI发病后，高浓度B型钠尿肽可提示低左室射血分数。关键词急性心肌梗死；预后；肌钙蛋白I；B型钠尿肽2·英文论著摘要·Area Under Curve of Cardiac Troponin I、BNP and Recent Prognosis of AMI undergoing PCIObjectiveTo explore the prognostic value of aTea under the curve of cardiac troponin I andBNP in 30 days in STEMI undergoing PCI．Methods26 patient S、析也ST elevated acute myocardial infarction for the first time were admitted，in whom percutaneous coronary intervention was successfully proceeded． The levels of plasma cTnl were measured at 6h，1 2h，24h，48h and 72h after admission．And echoeardiography was performed within 1 0 days after AMI attacked． The levels of plasma BNP were measured within 24h．According to the status of infarctrelated artery within 6 hours，all the patients were divided into patent group andoccluded group．And echocardiography Was performed within 1 0 days after admission in all patients，recording left ventricular end—diastolic·volume and left ventricular ejection fraction(LVEF)．In 30 days follow up，clinical terminal events(death andheart failure)were recorded．Results(1)The area under culNe of cTrd and CK-MB had no correlation with 30 days prognosis of STEMI．As the same as left ventricular end—diastolic volume；(2)the levels of BNP and LVEF had significant correlation、析tIl 30 days prognosis of STEMI(刚．01)．The ROC curves confirmed BNP and LVEF were factors that could predictrecent adveme