环氧化酶2与宫颈癌关系的初步研究-妇产科学专业论文.docxVIP

PAGE PAGE 3 性差异 (P0.05)o 3.COX-2 的表达在宫颈鳞癌放疗前、后组织中存 在明显变化，差异具有显著性 (Z=3.l92. P=O.OOlO.05)o COX-2 在 完全缓解组 (CR)放疗前、启富颈组织中的表达存在统计学意义，放疗 后 COX-2 明显下降 (Z=-2.647 ，P=O.0080.01); COX之在部分缓解 组 (PR)放疗前、后 COX-2 的表达呈下降趋势，但无统计学意义 (Z=-1.652，P=O.099O.05) 。两种不问疗效组之间放疗后COX-2 的表 达差异具有统计学意义 (Z=-2.923，扣0.0030.05) ，完全缓解组放疗 后 COX-2 的表达下降更明显。结论: 1.COX-2 在正常子宫颈组织无 表达，在宫颈上皮内瘤变组织表达增加，在宫颈癌组织中强表达，随 宫颈病变程度加重 COX-2 表达增强，提示 COX♂可能参与宫颈癌的 发生发展过程。 2.COX♂在腺癌中的表达明显高于鳞癌， COX-2 夜 宵颈鳞癌组织中的表达量与淋巴结转移、间质浸润深度相关，与临床 分期、病灶大小、组织学分级之间无显著差异，提示 COX-2 可能参与 宫颈的侵袭及转移。 3.COX-2 的表达在宫颈鳞癌放疗前、后组织中存 在明显差异，放疗后 COX♂表达总体盟显著下降趋势;且在放疗后 完全缓解组 (CR)中下降更明显，在部分缓解组 (PR)中表达呈下降 趋势，但无统计学意义，提示 COX-2 的表达与宫颈癌的放疗疗效相 关。 关键词:宫颈癌:宫颈上皮内瘤变;环氧化酶…2; 免疫组织化学: 放疗 TO study the relatio?ship of COX2 with cervical carCI?oma Abstract: Objective: To study the expression of COX♂in different cervix tissues(nonnal cervix，cervical intraepithelial neoplasia(CIN) ， cervical carcinoma) by Immunohistochemistry and the relationship with c1inicalpathological factors. 丁o detect the expression of COX♂1ll advanced cervical squamous carcinoma before and after radiotherapy. Methods: Immunohistochemistry was used to test the expression of COX-2 in nonnal 、CIN and cervical carcinoma respectively and the expression of COX-2 in squamous cancer before and after radiotherapy. 1: test and Mann响iteney test wωused，when P0.05 ，it has statistical significance. Result: I.COX-2 was absent in nonnal cervix，while the positive express rate in CIN and cervical c盯cinoma was 56.67%，88.52% respectivel弘丁he total difference in three groups was significant (沪39.01 ，P=0.0000.05)，the difference in ev町 couple group is significant (P0.05).2. 丁he positive expression of COX♂1ll adenocarcinoma was 91.67%. 丁he positive expression of COX♂m squamous carcinoma was 87.76%.The expression of COX♂was significantly increased in adenocarcinoma compared with squamous carcinoma(Z=-3 .3 14，P=O.OOlO.05). The expression of COX-2 was rel