蒙药材荜茇、接骨木和漏芦花中生物碱的研究-有机化学专业毕业论文.docxVIP

摘 摘 要 蒙药材化学成分研究是开发蒙药材资源，开展蒙药研究和实现蒙药现代化的基 础性研究。本文就目前蒙药的发展概况和植物蒙药材的化学成分研究尤其是生物碱 的研究作了综述，选取三种有代表性的蒙药材荜茇、接骨木和漏芦花作为研究对象， 借鉴中药材在生物碱研究方面的经验，确定了含量测定最佳条件，对三种蒙药材进 行了含量测定；首次对其生物碱提取液进行了体外抗氧化性研究；并首次采用硅胶 柱色谱分离法对三种蒙药材生物碱进行了大量的提取和分离工作，取得了喜人的成 果。结果表明荜茇、接骨木和漏芦花中均含有一定量生物碱，且对羟自由基、超氧 阴离子和H：O：具有清除作用；从荜茇中提取分离出胡椒碱。蒙药材荜茇、接骨木和 漏芦花中生物碱的研究工作为今后进一步对其药理研究提供了依据，丰富了三种蒙 药材化学成分的研究工作，为其他蒙药材中生物碱以及其他成分的研究提供了借 鉴，同时也为研制开发新型的药物提供了一些基础资料。 关键词：荜茇；接骨木；漏芦花；提取；分离；胡椒碱 Studies Studies on the Alkaloids of Mongolian Medicine Piperis Longi Sambucus Williamsii Hance and Rhaponticum Uniflorum ／Lhstract The study on chemical constituents of Mongolian medicine is the basic research in developing resources and carrying out researches of Mongolian medicine and in realizing modernization of Mongolian medicine．In this paper，the general situation of Mongolian medicine and chemical components of herbal medicine--especially of alkaloid-一ale summarized．Three representative Mongolian medicine--Piperis Longi，Sambucus Williamsii Hance and Rhaponticum Uniflorum ale selected as subjects．Using the cxperience for reference in alkaloid researches on Chinese traditional medicine，this paper ascertains the best conditions for content menstruation and determines the contents of the three representative Mongolian medicine．Besides，in this paper,the study on its in vitro antioxygen of alkaloid iS first carried Out．By adopting silica gel chromamgraphic columnSeparation．much work is done on the extraction and isolation of the three Mongolian medicine alkaloid，which receives a pleasant result．The result shows that Piperis Longi，Sambucus Williamsii Hance and Rhaponticum Uniflorum all contain some 锄0unt of alkaloid,which call get rid of-OH、晚一和H!02．Piperine is extracted and isolated from Piperis Longi．．The study on alkaloid in Mongolian medicine Piperis Longi．Sambucus Williamsii I-lance and Rhaponticum Uniflorum provides basis for its further pharmacological researches and enriches the study on chemical components of the three Mongolian med