复旦大学上海医学院妇产科学系2009级六年制妇产科学课件 Gestational Trophoblastic Disease (GTD).ppt

Gestational Trophoblastic Disease (GTD) Kang Yu Obstetric Gynecology Hospital of Fudan Universtity 2013-11-26 Objectives Section I Brief Summary of GTD Section II Clinical Probation Case I Case II Case III Section III Bedside-to-Bench (and Back) Trophoblast and cancer Research design example KEY TERMS AND DEFINITIONS Hydatidiform Mole. A placental abnormality involving swollen placental villi and trophoblastic hyperplasia with loss of fetal blood vessels. There are two types: complete and partial. Complete Mole. A molar pregnancy with swelling of all placental villi. Fetal tissues are absent. Partial Mole. A molar pregnancy with some normal and some swollen villi plus fetal, cord, and/or amniotic membrane elements. KEY TERMS AND DEFINITIONS Invasive Mole. A variant of hydatidiform mole in which the hydropic villi invade the myometrium or blood vessels. It may spread to extrauterine sites. Choriocarcinoma. A morphologic term applied to a highly malignant type of trophoblastic neoplasia in which both the cytotrophoblast and syncytiotrophoblast grow in a malignant fashion. PSTT. A rare type of GTD arising in the uterus that secretes human placental lactogen (hPL) and human chorionic gonadotrophin (HCG). Section II Clinical Probation Case I Case II Case III Section III Bedside-to-Bench (and Back)  Trophoblast and cancer Research design example * * GTD is… A group of disorders in which trophoblastic tissue proliferates abnormally GTD includes: Benign Hydatidiform mole (complete or incomplete) Malignant (Gestational Trophoblastic Neoplasia, GTN) Invasive mole Choriocarcinoma Placental site trophoblastic tumor (PSTT) GTN is remarkable because… One of the few malignant disease which can be cured Has very high rates of response to chemotherapy Has a tumor marker (β- HCG) that is… highly sensitive and 100% specific (normal pregnancy excluded) Song Hongzhao (1915 - 2000 ) In 1994 was elected to the Chinese Academy of Engine