黄芪甲苷葡萄糖注射液治疗冠心病稳定型劳累性心绞痛的Ⅱ期临床分析-中西医结合临床专业毕业论文.docxVIP

成都中医药大学硕士学位论文 成都中医药大学硕士学位论文 中文摘要 目 的：观察黄芪甲苷葡萄糖注射液治疗冠心病稳定型劳累性心绞痛的有效性和 安全性。 方 法: 从成都中医药大学心血管内科门诊及住院部收集 132 例符合稳定型劳累 性心绞痛诊断标准的患者，采取随机、仿盲、阳性药平行对照设计，分为试验组（大、 中、小剂量组）与对照组共 4 组。试验组静脉滴注黄芪甲苷葡萄糖注射液，对照组静脉 滴注丹参注射液治疗，疗程 2 周，观察治疗前后各症状记分及相关检查变化情况。 结 果: 本次临床试验结果表明了黄芪甲苷葡萄糖注射液对冠心病心绞痛有较 好治疗作用，能明显缓解心绞痛以及改善心肌缺血，试验组与对照组治疗效果无显著差 异（P＞0.05）。试验药物组低、中、高剂量尤其是低剂量组的疗效均有比对照组更高的 趋势，其中低剂量组对心电图的改善（显效率）显著优于对照组（P＜0.05）。试验过程 中，未发生严重不良事件，未发现试验药物各组,安全性指标出现与试验药物有关的治疗 前正常/治疗后异常或治疗前异常/治疗后异常加重的情况。 结 论：黄芪甲苷葡萄糖注射液治疗冠心病稳定型劳累性心绞痛疗效肯定，安全 可靠。 关键词：冠心病 稳定型劳累性心绞痛 黄芪甲苷注射液 Abstract Objective: To investigate the clinical effect and security of Astragaloside IV Glucose on angina of coronary artery disease. Methods: 132 cases of angina of coronary artery disease were enrolled from the clinic and admission department of heart Medical Department of ChengDu university of TCM. we adopted parallel control and imitated blind design with positive control medicine. They were randomly devided into treatment group which including 3 classes of high dose,medium dose and low dose and control group. Treatment group were treated with Astragaloside IV Glucose, while control group were treated with Salvia miltiorrhiza injection. The period of treatment was 2 weeks.the symptoms and signs were observed both before and after treatment. The correlative eximations were taken both before and after treatment. Result：The clinical test showed Astragaloside IV Glucose has good effect on angina of coronary artery disease ,which could relieve angina obviously and myocardial ischemia. there was no significant difference(P0.05). The treatment group especially low dose group have better therapeutic effect than control group. The low dose group had better effect for execellence in ECG improvement. During treating, there is no Severity side effect on patients health in both treated group and controlled group. That safety index of trial medicine groups up worsening conditions like pretherapy normality / post-treatment abnormality or pretherapy a