黄芪甲苷葡萄糖注射液治疗冠心病稳定型劳累性心绞痛的Ⅲ期临床分析-中西医结合临床专业毕业论文.docx

成都中医药大学硕士学位论文 成都中医药大学硕士学位论文 PAGE PAGE 2 中文摘要 目的：观察黄芪甲苷葡萄糖注射液治疗冠心病稳定型心绞痛的有效 性和安全性。 方法：从成都中医药大学、天津中医学院、贵阳中医学院及新疆维吾 尔自治区中医医院心血管内科门诊及住院部收集 432 例符合稳定型 劳累性心绞痛诊断标准的患者，采取随机、仿盲、阳性药平行对照设 计，分为试验组与对照组两组。试验组静脉滴注黄芪甲苷葡萄糖注射 液治疗，对照组静脉滴注丹参注射液治疗，疗程 2 周，观察治疗前后 各症状计分及相关检查变化情况。 结果：本次临床试验结果表明黄芪甲苷葡萄糖注射液对冠心病稳定型 心绞痛有较好的疗效，能明显缓解心绞痛及改善心肌缺血，试验组与 对照组治疗效果无显著差异（P0. 05）。试验过程中，未发生严重不 良事件，以及发现试验药物各组安全性指标未出现与试验药物有关的 治疗前正常/ 治疗后异常或治疗前异常/ 治疗后异常加重的情况。 结论：黄芪甲苷葡萄糖注射液治疗冠心病稳定型心绞痛疗效肯定，安 全有效。 关键词：冠心病 稳定型劳累性心绞痛 黄芪甲苷葡萄糖注射液 Abstract Objection:To investigate the clinical efficacy and security of Astragaloside Ⅳ Glucose on stable angine of coronary artery disease. Methods:432 cases of stable angine of coronary artery disease were enrolled from the clinic and admission department of heart Medical Department of chengdu、tianjin and guiyang university of TCM and traditional chinese medicine hospital of xinjiang weiwuer autonomous regine. We adopted stochastic and parallel control and immitated blind with positive control medicine.Treament group were treated with Astragaloside Ⅳ Glucose,while control group were treated with Salvia miltiorrhize injection.The course of treatment was two weeks.The symptoms and signs were observed both before and after treatment.The correlative eximations were taken before and after treatment. Result:The clinical test showed Astragaloside Ⅳ Glucose has good effect on stable angina of coronary artery disease，which could relieve angina and improve myocardial ischemia obviously.The therapeatic efficacy between treament group and control group without significant deviation. No obvious side effect was afound during treating.That safety index of trial medicine groups conditions like pretherapy normality / post-treatment abnormality or pretherapy abnormality/ post-treatment abnormality worsen which has some relationship with trial medicine groups were not discovered. Conclusion: Astragaloside Ⅳ Glucose can improve clinical symptom of stable angine of coronary artery disease.And it