金葡素、奥沙利铂腹腔内注射联合射频透热治疗恶性腹水的临床研究.docVIP

金葡素、奥沙利钳腹腔内注射联合射频透热治疗恶性腹水的 临床研究 张为强 王玮 周聆赵仔君 王玉树 (上海市闸北区市北医院上海闸北200435) 【摘要】口的：探讨金葡素、奥沙利钳腹腔内注射联合射频透热治疗恶性 腹水的治疗效果。方法：病人分为治疗组和对照组，其中治疗组30例，腹腔内 注入金葡素80ml＞奥沙利钳200mg/m2 +5%葡萄糖水100ml,地塞米松10mg及 利卡因10ml；即行射频热疗，一周3次。对照组30例，腹腔内注入金葡素80ml. 奥沙利钳200mg/m2 +5%葡萄糖水100ml,地塞米松10mg及利卡因10mlo结果： 治疗组和对照组治疗腹水的有效率分别为80.0%,53.33%,两组比较差异有显著性 (Plt;0.05)o结论：金葡素、奥沙利钳腹腔内注射联合射频透热治疗恶性腹水 有明显的治疗效果。 【关键词】恶性腹水；金葡素；奥沙利钳；射频透热 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752 (2015) 24-0121-03 Study of intraperitoneal infusion of staphylococcus enterotoxin and oxaliplatin combined with radiofrequency hyperthermia in the treatment of malignant ascites Zhang Weiqiang,Wangwei’Zhoulin,Zhao Zijun’Wang Yuesu Department of Oncology, Shanghai Zhabei Hospital,Shanghai 200435,China [Abstract] Objective: To evaluate the therapeutic effects and adverse reaction of intraperitoneal infusion of staphyiococcus enterotoxin(SE) and oxaliplatin(Oxa) combined with radiofrequency hyperthermia in the treatment of malignant ascites. Methods: A total of 60 cases with malignant ascites were divided into 2 groups. The treatment group (n二30) was treated with SE and oxaliplatin and radiofrequency hyperthermia.The control group(n二30) was treated with SE and oxaliplatin.Results: For the treatment group,CR+PR 80%; the control group, CR+PR 53.33 %.There were significant differences between the two groups (Plt;0.01).Combined use with SE and Oxa and hyperthermia did not in crease the toxicity. Conclusion:The intraperitoneal infusion of staphylococcus enterotoxin(SE) and oxaliplatin combined with radiofrequency hyperthermia in the treatment of malignant ascites is significantly more effective than that with staphylococcus enterotoxin(SE) and oxaliplati n. 【Kwy words】 staphyiococcus enterotoxin; oxaliplatin; radiofrequency hyperthermia; malignant ascites 恶性腹水是晚期恶性肿瘤常见并发症，大量腹水严重影响患者的生活质量。 目前临床上治疗恶性腹水的方法主要有利尿剂、腹腔穿刺排液、腹腔内化疗及免 疫治疗等，但疗效均不尽如人意。笔者采用金葡素、奥沙利钳腹腔内注射联合射 频透热治疗恶性腹腔积液，取得较满意的疗效，现报告如下。 ?资料与方法 1.1 一般资料 选取2013年1月?2015年2月我科收治的恶性腹水患者60例，按随机数 字表法随机分成治疗组和对照组，