食管癌放疗致食管炎护理的Meta分析.docVIP

食管癌放疗致食管炎护理的Meta分析 常双柯昌云肖劲松刘瑞赵静通讯作者 湖北医药学院附属太和医院湖北十垠442000 【摘 要】目的：系统性评价综合护理与常规护理用于食管癌放射治疗致食 管炎的临床效果。方法：计算机检索7种数据库，时间截止至2013年8月底。 纳入综合护理与常规护理用于食管癌放射治疗致食管炎的随机对照实验，采用 Revman5.1软件进行Meta分析。结果：11篇随机对照试验符合纳入标准。放射 性食管炎发生率(OR： 0.37, 95%CI： 0.28-0.48； Plt;0.0001)＞不同放射剂量 3?4级放射性食管炎发生率(OR： 0.43, 95%CI： 0.31?0.59； Plt;0.0001)综合 护理明显低于常规护理，两组差异有统计学意义。结论：综合护理能有效减低放 射性食管炎发牛率及严重程度，产牛统一的食管癌放射治疗致食管炎护理指南及 路径，有待于今后设计严谨，多中心的随机对照试验。 【关键词】食管癌；放射治疗；放射性食管炎；护理干预；Meta分析 【中图分类号】R473 【文献标识码】B 【文章编号】1674-8999 ( 2015 ) 8-0102-02 Meta-analysis of esophageal cancer radiation esophagitis nursing Cha ng Shuang Ke cha ng yun Xiao Jin?song Zhao Jing* (Taihe Hospital, Hubei University of medicine, Hubei 442000,Shiyan,China) [Abstract】Objective:To evaluate the clinical efficacy of comprehensive nursing intervention and routine nursing intervention in esophageal radiation esophagitis patients.Methods:Data from 7 databases were retrieved for this study.Search time from the first published to the end of August 2O14.The RCTs of comprehensive nursing intervention and routine nursing intervention in esophageal radiation esophagitis patients were included.A meta-analysis was performed with Revman 5.1 sof t wa re. Res u 11 s: EI eve n RCTs met the inclusion criteria.The Radioactive esophagitis incidence (odds ratio (OR): 0.37, 95%CI： 0.28?0.48； Plt;0.0001), and different dose level 3-4 radioactive esophagitis incidence(OR： 0.43,95%CI： 0.31 ?0.59； Plt;0.0001) were sign讦icantly lower in comprehensive nursing intervention group than routine nursing intervention group,and this differenee was statistically sign讦icant between the 2 groups.Conclusions: Comprehensive nursing intervention can effectively reduce the in cide nee and severity of radiati on esophagitis .In order to develop untied esophageal cancer radiotherapy induced esophagitis nursing guidelines and clinical pathways multi-ce nt re RCT with a rigorous desig n is n eeded in the future. [Key words] Esophageal cancer； Radiotherapy； Radiati on esophagitis； Nu