三维适形与常规放射治疗鼻咽癌的队列研究及局部区域复发的分析-肿瘤学专业论文.docxVIP

三维适形与常规放射泊疗鼻咽癌的队列研究及局部区域复发的分析 关节的晚期放射后遗症 。剂量学分析显示，肿瘤抗拒导致的野内和野边缘复发占多数，而 靶区勾画的范围不足导致的野外仍占一定比例。强烈建议对鼻咽癌患者放疗前进行 MRI 的检查，以保证靶区勾画的准确性。提高放射治疗医生的阅片水平和对肿瘤生物学行为的 认识水平对提高三维放射治疗的疗效有重要作用。 关键词:三维适形放射治疗鼻咽肿瘤 队列研究复发剂量学分析 II 三维适形与常规放射治疗鼻咽癌的队列研究及局部区域复发的分析A 三维适形与常规放射治疗鼻咽癌的队列研究及局部区域复发的分析 A Matched Cohort Analysis Of Three Dimensional Conformal Radiotherapy Vs．Conventional Radiotherapy For Patients With Primary Nasopharyngeal Carcinoma And Dosimetric Analysis of Locoregional Recurrence Postgraduate：Tang Yiqiang Tutor：Luo Wei Department of Radiation Therapy，Cancer Center,Sun Yat-sen University，Guangzhou China，510080 ABSTRACT BACKGROUNDOBJECTIVE The purpose of this research is to explore whether three dimensional conformal radiotherapy(3D CRT)increased the locoregional control and reduced the probability of late complications for patients with primary nasopharyngeal carcinoma when comparing with conventional radiotherapy(CRT)．Dosimetric analysis was done to。probe the causes of locoregional failure． MATERIALS AND METHODS 1 1 4 patients with primary nasopharyngeal carcinoma treated by 3D conformal radiotherapy during February，200 1 and April，2004 were retrospectively reviewed．These 三维适形与常规放射治疗鼻咽癌的队列研究及局部区域复发的分析patients 三维适形与常规放射治疗鼻咽癌的队列研究及局部区域复发的分析 patients were then compared with a cohort of 1 1 4 patients treated by conventional radiotherapy between January,2002 and December,2003，who were matched with respect to 92’Fuzhou stage，T stage，N stage，sex and age．The 4 years overall survival rate，progress—free survival rate，local relapse-free survival rate，regional relapse—free survival rate and distant metastasis—free survival rate were compared．Dosimetric analysis for patients with Iocoregionai relapse were performed． RESUIJS A total of 6 patients(5．3％)had local failures and 2 patients(1．8％)had regional failures in both 3DCRT group and CRT group respectively．The 4 years locoregional relapse-free survival rates were 91．96％and 90．03％(P=0．8759)，respectively，and the 4 years overall survival rate