流感嗜血杆菌菌毛基因簇的生物信息学分析及分析软件测评-动物学专业论文.docxVIP

Title：Bio．informatics Title：Bio．informatics Analysis of Haemophilus Influenzae Frimbrial Gene Cluster and Test of Analysis Software Major：Zoology Name：Wang Xin Supervisor：Hc M／ao，Ph．D， Abstract Along with the rapid development of Bio-informatics，the emphasis is tending towards to the study of prOteomics and genomic,which is more essential than configuration and physiology．It accords to the developing regular pattern of science to guide the research and development of traditional biology based oil the study of proteomies and genomic。 The haemophilus influenzae Rd is the first bacilli to be used in sequence test．The genome of haemophilus infiuenzae Rd is 1，830，138bp．T1GR has confirmed that it has 1,473 genes with very important functions．髓e haemophilus influenzae Rd strain is us-pathogenic capsulated experimentation bacteria；virulence genes still havn’t not be tested+though the genome test has akeady been completed． 确e haemophilus influenzae b is pathogenie capsulated strain．The genome sequence includes coding bacterium genes hifA，B、C，D、E that agglomerate the erythrocyte，and so on。霹le haemophilus influenzae LKP strain is pathogenic non．encapsulated strain．The study of haemophilus influenzae finabrial virulence gene cluster sequence definitely has very important meaning to discovering the genes that caused disease，and the antigen genes．It will also very important for filter the medicine-effecting target，and developing diagnoses reagent，medicine，and bacterin． This mtide studies three kinds of haemophilus influenzae bacterium virulence genes through applying the popular Bin—informatics software．no objective is to compare and analyze the difference of hifA，B，C，D、E gene sequence、and proteide sequence between haemophilus infiuenzae b and LKP Strain，and the difference or common between protein structural site and structure*functional domain；to study the base of ganomic and proteomics sequence,and sequence character of hib and hif-删Strain that caused pathogenic；to ana