抗生素的血药浓度PKPD approach for antibioticstissue or blood drug level to predict antibiotic efficacy.pptVIP

PK/PD approach for antibiotics: tissue or blood drug level to predict antibiotic efficacy PL Toutain National Veterinary school; Toulouse First (scientific) consensus:The goal of PK/PD indices The goal of PK/PD indices is to predict, in vivo, clinical outcomes: Cure prevention of resistance Plasma free concentration is the relevant concentration for the establishment of a PKPD indice Second (marketing) consensus It is more easy to promote a macrolide showing its high lung concentrations than its low plasma concentrations PK/PD approach for antibiotics: tissue or blood drug level to pre