磷脂酸在植物中的第二信使功能-中国生物化学与分子生物学报.PDF

ISSN 中国生物化学与分子生物学报 2006 年 9 月 CN 　113870Q Chinese Journal of Biochemistry and Molecular Biology 22 (9) :697～703 ·综述· 磷脂酸在植物中的第二信使功能 王炎钦 , 　董海涛 (浙江大学 生物技术研究所 , 杭州　310029) ( ) 摘要 　磷脂酸 phosphatidic acid , PA 是植物中重要的细胞内信号分子 ,被称为“脂质第二信使”,特 别是几个 PA 的作用靶点已被克隆和鉴定. 植物体内 PA 的产生可以通过磷脂酶 C 和 D 两条信号通 路 ,前者与甘油二酯激酶协同作用. PA 主要由各种生物和非生物胁迫诱导产生 ,磷脂酸的水平在各 种胁迫处理后的几分钟内增强. 增强的信号水平通过 PA 的磷酸化形成甘油二酯焦磷酸而被迅速 减弱. 本文就 PA 产生的磷脂酶信号通路 ,PA 在各种胁迫诱导下的产生 ,PA 的作用靶点和作用机理 及在植物中的功能等几个方面进行综述. 关键词 　脂质信号 ;磷脂酸 ;第二信使 ;磷脂酶 ;胁迫 中图分类号 　Q9465 Biological Function of Phosphatidic Acid as a Second Messenger in Plants WANG YanQin , DONG HaiTao ( Institute of Biotechnology , Zhejiang University , Hangzhou 　310029 , China) Abstract 　Phosphatidic acid (PA) is an important intracellular signal molecule and is called the lipid second messenger because several targets of PA have especially been cloned and identified. Production of PA in vivo in plants is through the pathways of two signals of phospholipases C and D , and the former induces effect in cooperation with diacylglycerol kinase. PA is produced mainly via various biotic and abiotic stress conditions , and level of PA increases within minutes after a wide variety of stress treatments including pathogen elicitation , drought , salinity , wounding , cold and freezing , ethylene , abscisic acid and oxidative stress. Enhanced signal levels is rapidly attenuated through the formation of diacylglycerol pyrophosphate via phosphory