抗焦虑治疗对广泛性焦虑障碍共病2型糖尿病患者血糖水平的影响.docVIP

抗焦虑治疗对广泛性焦虑障碍共病2型糖尿病患者血糖水平 的影响 江斌1沈仲夏2(通讯 )蔡敏2 摘 要 目的 探讨广泛性焦虑障碍(GAD)共病2型糖尿病患者抗焦 虑治疗前后血糖水平的变化。方法 采用前瞻性研究，所有GAD共病2型糖尿 病患者72例均接受艾司西駄普兰抗焦虑治疗8周。用空腹血糖，餐后2小时血 糖，糖化血红蛋白评估患者血糖水平，用汉密尔顿焦虑量表(HAMA)评估患者 焦虑严重程度及疗效，比较治疗前后研究对象血糖水平的变化并比较GAD不同 疗效间和血糖变化水平的差别。结果治疗前后患者HAMA评分分别为 (18.42plusmn;2.38)和(6.76plusmn;4.34) (t=20.00 , P二0.000)。治疗后平 均空腹血糖为(6.58plusmn;1.90)mmol/L,显著低于治疗前(8.21plusmn;1.59) mmol/L (t=5.58, P二0.000)。餐后 2 小时血糖(10.67plusmn;2.84) mmol/L,显 著低于治疗前(13.11plusmn;3.40) mmol/L (t=4.67, P二0.000)。糖化血红蛋白 (7.49plusmn;1.34) %,也显著低于治疗前(8.42plusmn;1.23) % (t=4.23 , P=0.000)o治愈组平均空腹血糖下降(2.65plusmn;1.56) mmol/L,显著高于非 治愈组(0.77plusmn;1.60) mmol/L (t=4.87, P=0.000)；治愈组餐后 2 小时血糖 卜降(3.48plusmn;2.18)mmol/L,显著高于非治愈组(1.49plusmn;l.95)mmol/L (t=3.86, P=0.000)；治愈组糖化血红蛋白下降(1.66plusmn;1.48) %,也显著 高于非治愈组(0.53plusmn;0.82) % (t=3.59 , P二0.001)。结论 抗焦虑治疗可 以改善GAD共病2型糖尿病患者的血糖水平。 关键词 广泛性焦虑障碍；2型糖尿病；血糖水平；抗焦虑治疗 The effect of the treatment of Generalized Anxiety Disorder(GAD) on the glucose level of Type 2 Diabetes Mellitus(T2DM). Jiang Bini, Shen Zhongxia2 ,Cai Min2. 1. the Four Peoples Hospital of Haining City, Haining 314411, Zhejiang, China;2.the Third Peoples Hospital of Huzhou City, Huzhou 313000, Zhejiang, China [Abtract] Objective To explore the treatment of GAD on the glucose level of T2DM by comparing the glucose levels before and after the treatment of GAD patients who commodity T2DM? Methods Perspective methods was applied to the 72 cases who meet the research criteria, and all the cases were treated with Escitalopram for 8 weeks. To evaluate the glucose with fasti ng blood glucose(FBG), postprandial blood glucose(PBG), glycosylated hemoglobin(HbAlc). The anxiety status and efficacy was evaluated with HAMA. To compare the glucose levels before and after the treatment of GAD, and compare the change of glucose level between the patients who achieved remission and who has not. Results The HAMA scores before and after the treatment is (18.42plusmn;2.38) vs. (6.76plusmn;4.34) (t=19.988, P=0.000) respect