肝性脑病课件2019.ppt

Improved stage in chronic encephalopathy vs. placebo Elkington, NEJM 1973 70% of patients improve an long term therapy  Conn, Gastroenterology 1977 Psychometric tests improve after 3 weeks under lactulose  McCain, J Clin Gastro 1984 Crossover studies show improvement in psychometric tests Morgan, J.Hepatol 1989 Both low and high doses of lactitol significantly lower Ammonia levels, but only high doses improve psychomotor tests Salerno, J.Hepatol 1994 Subclinical HE disappears in 50