土大黄及其有效成分药理活性研究进展-中药新药与临床药理.docVIP

土大黄及其有效成分药理活性研究进展 张红阳，李波，钟国跃，王洪玲，朱继孝作者简介：张红阳，女，在读硕士生，研究方向 作者简介：张红阳，女，在读硕士生，研究方向：民族药物有效成分及作用机理研究，E-mail: 497794376@ * 通讯作者：朱继孝，博士，副教授，硕士生导师，研究方向：中药与民族药有效成分与作用机理， E-mail: zhujx81@ 基金项目：横向合作项目“3种中药材药效学评价及活性成分筛选研究”。 摘要：土大黄药用历史悠久，为维吾尔医常用药材。近年来，国内外学者对土大黄的化学组成、药理活性进行了较为广泛的研究。成分分析表明，土大黄以蒽醌类、黄酮类、萘及萘醌类、二苯乙烯类等成分为主; 药理实验及临床报道表明，土大黄在抗炎、抗病毒、抗肿瘤、抗氧化和抗免疫等方面具有重要作用。因此，对土大黄的各个有效成分的活性总结具有临床指示性意义。本文通过查阅国内外相关文献，总结了土大黄不同活性成分的药理活性及作用机制，为该药临床研究提供理论依据，以期为其开发利用提供依据。 关键词：土大黄；有效成分；药理作用 Advances in pharmacological activities of active constituents in Rumex madaio ZHANG Hong-yang, LI Bo, ZHONG Guo-yue, WANG Hong-ling, ZHU Ji-xiao (Research Center for Traditional Chinese Medicine Resources and Ethnic Minority, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004 Jiangxi, China;) Abstract: Rumex madaio is a common medicine for Uighur medicine with a long history. In recent years, scholars at home and abroad have studied the chemical constituents and pharmacological activities of Rumex madaio. Component analysis showed that soil with Anthraquinones, flavonoids, naphthalene and naphthalene quinones, two styrene and other components in Rumex madaio; and reports of clinical pharmacological tests show that Rumex madaio has an important role in anti-inflammatory, antiviral, antitumor, antioxidant and anti immune. Therefore, it is of clinical significance to summarize the activity of various active constituents of Rumex madaio. In this paper, the pharmacological activities and mechanisms of different active components of Rumex madaio were summarized through literature review, which provided a theoretical basis for the clinical study of the Chinese medicine, and provide a the future basis for its development and utilization. Key word: Rumex madaio; effective constituents; pharmacological action 土大黄为蓼科(Polygonaceae) 植物酸模属(Rumex) 巴天酸模(R. patientia) 、羊蹄(R. japonics) 、酸模(R. acetosa) 、皱叶酸模(R. crispus) 、尼泊尔酸模(R. nepalensis) 、毛脉酸模(R. gmelinii)、网果酸模(R. chalepensis)等药用植物的根及根茎[1]。其性凉，味辛、苦，具有生干生寒、清热补肝、