新城疫及其防治.ppt

* 7 * * * * * * * What is the problem of vaccination with the old lentogenic pneumotropic vaccines?传统的嗜呼吸道型疫苗所产生的问题 3 Post-vaccination Reaction 免疫反应 PVR THE RESPIRATORY DISEASES COMPLEX呼吸道疾病的诱因 Production system 生殖系统 (young and immature animals) Genetic遗传 (cardio-pulmonary system 心肺系统) Density 密度 (farm, area) Multiple viral infections多重病毒感染 (immunosuppression, lesions) Toxics有害物 (air - water) 空气 - 水 Feed 饲料 (fungi and mycotoxins) 霉菌和霉菌毒素 Microbism 病原维生物 (antibioresistance) ND VACCINATIONS 免疫反应 Post-vaccination Reaction 免疫反应 Normal consequences of pneumotropic vaccine 常见于嗜呼吸道型 疫苗 Pneumotropic: Replicate in the respiratory tract (target tissus) and probably participate at the C.R.D. Lentogenic: Residual pathogenicity not to be underestimated 嗜呼吸道型：呼吸道增殖，和CRD有关 缓发性：无法忽略其残留毒性 HB1, La Sota, Clone 30…. Post-vaccination Reaction 免疫反应 No or very little reaction with Enterotropic vaccines 嗜肠道型疫苗无免疫反应或反应极其轻微 Cevac? VITAPEST L 诗华卫鸡城: Enterotropic : Replicate at the level of the gut, none or very limited lesions at the level of the respiratory tract Apathogenic : Very little residual pathogenicity 嗜肠道型：肠道增殖，无呼吸道损伤或损伤极其轻微 非致病性：几乎无任何残留毒性 Severity varies according to 与其严重程度有关的因素: Residual pathogenicity of the vaccine (ICPI) Health status of the chickens (carrier state – Mg, Ms ，concurrent infection – IB. Immunosupressive agents ) Immune status of the chickens (M.D.A - level,uniformity) Vaccine application (size of the droplets, incomplete spraying) Comfort offered to the chickens following vaccination (environnemental conditions at the poultry house like temperature and ventilation) 疫苗残留致病力（ICPI) 鸡群健康状况（有无Mg,Ms，IB, 免疫抑制因素等） 鸡群免疫状况（母源抗体水平，抗体均匀度） 接种水平（雾滴大小，喷雾操作不当） 接种后鸡群舒适度（鸡舍环境条件，如温度、通风等） 免疫反应 Normal image (x 20) 完全正常 Lymphoid Infiltration : +++ Congestion : + (x 20) 淋巴细胞浸润及充血 Lymphoid Infiltration : +++ Congestion : ++ (x 40) 淋巴细胞浸润及充血 pne