黏膜免疫 研究生课件.ppt

Shigella flexneri, a cause of bacterial dysentery, infects intestinal epithelial cells, triggering activation of the NF?B pathway. Shigella flexneri binds to M cells and is translocated beneath the gut epithelium (first panel). The bacteria infect intestinal epithelial cells from their basal surface and are released into the cytoplasm (second panel). Muramyl tripeptides containing diaminopimelic acid in the cell walls of the shigellae bind to and oligomerize the protein NOD1. Oligomerized NOD1 binds the serine/ threonine kinase RIPK2, which triggers activation of the NF?B pathway , leading to