瑞舒伐他汀治疗急性脑梗死临床疗效观察.docVIP

瑞舒伐他汀治疗急性脑梗死临床疗效观察 李巧转季波江苏省泰兴市人民医院神经内科江苏泰兴 225400 作者简介:李巧转，女,(19 8 1 一),硕士研究生，主治医师，研究方向:急性脑血管病 的重症监护. 【摘要】目的探讨瑞舒伐他汀治疗急性脑梗死的临床疗效?方法选取 泰兴市人民医院神经内科2 0 1 4 - 0 6至20 1 5 — 0 3收治的急性脑梗死 患者8 4例为研究对象，随机分为治疗组和对照组.治疗组4 2例,在常规治疗的 基础上给予瑞舒伐他汀钙片治疗;对照组4 2例,给予常规治疗，包括抗血小板、管 理血压血糖、神经营养等，连续治疗3个月.记录比较两组患者治疗前、后血清超 敏C -反应蛋白(hs - CRP)和脂蛋白相关磷脂酶A 2 (Lp-PLA 2 )水平变化，并对患 者进行神经功能缺损程度评分，评价疗效.结果 两组治疗后血清Hs-CRP和Lp -PLA2均有明显降低，并且治疗组二者降低更明显(P 0??0 5);治疗组NHISS 评分显著低于对照组(P 0 ?? 0 5 );治疗组总有效率显著高于对照组(P V 0 ?? 0 5).结论 瑞伐他汀治疗急性脑梗死能够显著降低患者的NHISS评分，疗效显著.【关键词】 瑞舒伐他汀;急性脑梗死;超敏C -反应蛋白;脂蛋白相关磷脂酶A 2 CurativeEffectObservati ono fRosuvastati nintheTreatme ntofAcuteCerebrall nfarcti onJib o,Liqiao—zhuan’DepartmentofNeurology,TaixingPeoplersquo; sHospital,Jiangsu 2 2 5 4 0 0 ,China 【Abstract】:ObjectiveToexploretheclinicaleffectofrosuvastatininpatientswithacutec erebralinfarction??Methods: 8 4 patientswithacutecerebralinfarcG tion,whoweretreatedinTaixingPeoplersquo;sHospitalduringJune 2 0 14 toMarch 2 0 1 5 ,wererandomlydividedintotreatmentgroupandcontrolgroup??Treatmentgroup, 4 cases,wasgive nrosuvastati non thebasisofc onvention altreatme nt??Thec on trolgroupwa streatedwithc onvention altherapyforthreem on ths,incluG din gplateletaggregati on’con trolli ngbloodsugarandbloodpressurea ndprotectingbrainc ells??Thebeforea ndaftertreatme ntstatusof 2 groupsofpatie ntswasrecordeda ndcomparedo nthelevelsa ndcha ngesofserumhighse nsi tivityC - reactiveprotein(hs - CRP)andlipoprotein —associatedphospholipaseA 2 (Lp -PLA2 )?? Mea nwhile,patie ntsrsquo; neurologicaldeficitwerescoreda ndevaluated??Results:Th ehs —CRPandLp —PLA 2 inserumofpatie ntsfrombothgroupswereappare ntlydecreasedaftertreatme nt’an dthetr eatmentgrouphadmoresignificantdeclineonbothdata(P 0 ?? 0 5 )??Aftertreatment,theNHISSscoreinthetreatG mentgroupwasgreatlylowerthanthatofthecontrolgroup(P 0 ?? 0 5 ),thetotalefficiencyinthetreatmentgroupwasobviouslyhigherthanthatofthecontrolg roup [(KPeyw 0 ??or 0 d 5 s)] Concl usio n? ?:Rousvastati ntreatmentofacutecerebr