超敏反应和自身免疫教学课件.ppt

类风湿性关节炎Rheumatoid arthritis (RA) Joint inflammation Cell-mediated and humoral immune response Th1, Th17, B, macrophages, lymphoid follicles IL-1, IL-8, TNF, IL-6, IL-17, IFN-γ Joint destruction (collagenase, osteoclast) Rheumatoid factors (anti-IgG Fc Ab) Anti-CCP (cyclic citrullinated peptides) Ab (Arginine?citrulline) RA 患者手指关节实质性损伤 Pathogenesis of RA HLA-DR4 PTPN22 CCP(cyclic citrullinated peptides） Therapies : anti-TNF, anti-IL1, anti-IL-6R, CTLA-4, anti-IL-17, anti-CD20 Multiple sclerosis and experimental autoimmune encephalomyelitis Th1 and Th17 against myelin EAE model, Ags in CNS