肇庆地区新生儿先天性甲状腺功能减低症筛查分析.docVIP

肇庆地区新生儿先天性甲状腺功能减低症筛查分析 常剑锋 黄志伟 冼艳斌 胡雅 梁旭清(广东省肇庆市第二人民医院 526060 ) 【 】目的：分析肇庆地区新牛儿先天性甲状腺功能减低症(CH)筛查情况。 方法：对肇庆地区196541例新生儿采取荧光酶免疫分析法(FEIA)测定血促甲 状腺素(TSH)水平，可疑阳性者召回再次采集血液复查，阳性召回者采集静脉 血，采取化学发光法血测定T3、T4、TSH、FT3、FT4。结果：196541例新生儿检 出CH患儿126例,发病率1/1560 (0.64permil;),男性、女性发病率无显著差 异性，无统计学意义(p0.05)o接受正规治疗2?3年的患儿，停药30d随访， 绝大部分患儿身体、智力发育达到正常水平。结论：做好新生儿疾病筛查工作, 提高筛查率与召回复查率，尽早确诊与治疗，使人口素质增强，降低儿童病残率。 【关键词】先天性甲状腺功能减低症新生儿筛查 【中图分类号】R195 【文献标识码】A 【文章编号】2095-1752 (2013) 12-0074-02 Congenital hypothyroidism neonates in Zhaoqing to reduce disease screening an alysis Cha ng jianfeng Hua ng zhiwei, Xian yanbin, Huya, Liang xuqing (Guangdong pyovinee ZHaoqing Second Peoples Hospital,526060,China) [Abstract] Objectives: To analye the results of neonatal congenital hypothyroidism (CH) in Zhaoqing area.Processes: A total of 196541 cases new-born in Zhaoqing area were deliberately the level of serum thyroid-stimulating hormone (TSH) by using the fluoresce nt en zyme immunoassay (FEIA).lf the (TSH) result assumed musculi ne gender, then recollect the patients venous blood by using the chemiluminescenee method to determine the level of T3 T4 TSH FT3 and FT4.Results: 126 cases of children were confirmed from 196541 cases.The incidenee rate have no significant d iff ere nee betwee n male an female, and the differe nt betwee n male and female is too small to be statistically sign讦icance （Pgt;O.O5）.After two or three years formal treatment to the patient, the vast majority of childrens physical and intelligenee were developed into normal level after drug withdrawal for 30 days.Conclusions: We may diagnose and cure as soon as possible by accomplish the neonatal disease screening and improving the early screening and rechecking which can enhance the quality of population and reduce child morbidity. 【Key words】 congenital hypothyroidism newborn screening CH是因为先天因素造成甲状腺激素分泌障碍，属于儿科常见的内分泌 疾病［1］。CH主要临床特征为生长发育落后、智力低下、基础代谢率减弱。大部 分CH患儿的临床症状与体征缺乏特异性，易被忽视而延误诊断、治疗，对患儿 的身体、智力正常发育造成影响，其至致残。但CH可经筛查做到早期诊断与治 疗，防止患儿发生不可逆的智能障碍