篇影响药物效应因素.ppt

VI. Pathologic factors The liver is the main organ of drug metabolism. Hepatic dysfunction decreases drug metabolism, drug action will be prolonged. However, some drugs are transformed to the active forms in the liver, in this situation, drug effects will be decreased. Renal excretion plays a key role in final drug elimination. Renal failure will result in drug accumulation in the body, prolonging its effect. Cardiac disease Cardiac disease, by limiting blood flow to the liver, may depress the elimination of drugs whose metabolism is flow-limited and the clearance is perfusion-lim