不同时期增生性瘢痕患者血清中PⅢNP的浓度变化在瘢痕临床治疗中的意义.docxVIP

不同时期增生性瘢痕患者血清中PIIINP的浓度变化在瘢痕临床治疗中的意义 张凤刚刘婕婷沈锐徐路生陈晓东阮树斌杨荣华林颜 (广东省佛山市第一人民医院烧伤科 广东佛山528000) 【摘要】口的：研究不同时期增生性瘢痕患者血清+ PIIINP浓度变化的意 义及其对临床瘢痕治疗的指导意义。方法：选择2010年9月?2012年9月我科 收治住院的增生性瘢痕患者共100例，根据瘢痕增生的不同时期分5组。应用 ELISA法检测患者血清屮III型前胶原氨基端肽(PIIINP)的浓度变化，并比较PIIINP 的血清含量与瘢痕增生时段Z间的关系。结果：不同时期增生性瘢痕患者血清中 PIIINP含量和瘢痕增生时段关系密切，瘢痕增生早期，1?4个月患者血清屮PIII NP含量开始增加，随着增生性瘢痕的发展，其血清含量进一步的增加，到5?8 个月，PIIINP含量达到了高峰。伴随瘢痕的成熟，PIIINP浓度又逐渐下降。结论： PIIINP的浓度变化和瘢痕临床演进过程基本一致。同时证明了增生性瘢痕增生活 跃程度与瘢痕患者血清屮PIIINP的浓度呈定量的显著关系，可以作为临床不同 的瘢痕治疗方法的疗效评价及筛选的客观指标，具有指导意义。 【关键词】增生性瘢痕血清标记物III型前胶原氨基端肽 【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752 (2013) 34-0022-02 Change of serum concentration of amino-terminal propeptide of procollagen type III(PlIlNP) of hypertrophic scar at excessive stages and its clinical sign讦icance. Zhang Feng-Gang,Liu Jie-Ting ,Shen Rui, Xu Lu-Sheng,Chen Xiao-Dong,et al. IDepartment of burn and Plastic, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan 528000, China. 【Abstract] Objective To research the dose and the significances of amino-terminal propeptide of procollagen type III (PIIINP) in the serum of hypertrophic scar patients at excessive stages and favor making therapeutic regimen to cure hypertrophic scar. Methods Collect the serum samples of 100 cases inpatients admitted in our hospital from 2010,9 to 2012,9 suffering from Iong-persisting post-burned hypertrophic scar at various stages. Hypertrophic scar patients are divided into 5 groups according to the phase of scar and detect the concentrations of PlIlNP in serum of the trials using the sensitive ELISA method and analysis the relation between the doses of PlIlNP and proliferation degree of the scar. Results The dose of PlIlNP begin to rise in 1 to 4 months scar group and in creases gradually during the process of immature hypertrophic scar to mature scar before it achieves summit conce ntrati on in 5 to 8 mon ths scar group. The concen trati on of PlIlNP degreases gradually with the maturation of hypertrophic scar. Conclusions The dose of PlI