中性粒细胞计数淋巴细胞比值与晚期非小细胞肺癌临床病理关系及其在化疗中的意义.docxVIP

中性粒细胞计数淋巴细胞比值与晚期非小细胞肺癌临床病理关系及其在化疗中的意义 韩军胡宏燕 (安徽医科大学附属六安医院lt;六安市人民医院gt;呼吸内科237005) 【摘要】目的：探讨屮性粒细胞计数/淋巴细胞比值(NLR)与晚期非小细 胞帅癌(NSCLC)临床病理特征的关系，评价其对化疗的意义。方法：回顾性分 析84例晚期NSCLC临床病理资料，以NLR均值为临界值，将患者分为低NLR组 和高NLR组，分析NLR与NSCLC临床病理特征关系及NLR化疗前后的变化。结 果：NLR与肺癌病理分期、ECOG评分、血小板计数、血小板计数/淋巴细胞比值 (PLR)有统计学差异(Plt;0.05),与性别、年龄、吸烟史、病理类型、血红蛋 口(hgb)无统计学差异(Pgt;0.05)； NLR值化疗前4.11plusmn;2.94与化疗后 3.04plusmn;2.55 Z间的差异有统计学意义(Plt;0.005)。结论：NSCLC患者病 理分期越晚，NLR值越高；化疗后NRL值的降低对化疗评价有参考意义。 【关键词】屮性粒细胞计数/淋巴细胞比值；非小细胞肺癌；化疗 【屮图分类号】R730.2 【文献标识码】A 【文章编号】2095-1752 (2015) 23-0060-03 The relationship between neutrophil count/ lymphocyte ratio with advaneed non-small cell lung cancer pathology and its significance in chemotherapy Han Jun, Hu Hongyan. Luan Affiliated Hospital, Anhui Medical University( Luan people hospital), Anhui Provinee. Luan 237005, China 【Abstarct ] Objectiv To explore the relati on ship betwee n n eutrophil count/lymphocyte ratio (NLR) with advaneed non?small cell Iung cancer (NSCLC) clinical and pathological features,and to evaluate the significanee of chemotherapy.Methods Retrospective analysis of 84 patients with advaneed NSCLC clinical data, the patients were class讦ied into two groupsdow and high NLR group by the mean NLR as critical value, and then the association between NLR and clinicopathological features of NSCLC was analyzed. Result NLR with lung cancer staging, ECOG score, platelet count, platelet count/lymphocyte ratio (PLR) were sign ifica ntly d iff ere nt (Plt;0.05), but not with gen der, age, smoki ng history, histological type(Pgt;0.05); NLR value of the differenee between before and after chemotherapy was statistically sign讦icant (4.11 plusmn;2.94 and 3.04plusmn;2.55, respectively;? lt;0.005).Conclusion The later stage NSCLC patients with pathology, NLR value higher； there were ref ere nee sigrdficance of evaluati on of chemotherapy by NRL value reduced after chemotherapy 【Key words] Neutrophil count/-lymphocyte ratio; Non-small cell Iung cancer; Chemotherapy 肺癌是危害人类身体健康的恶性肿瘤