小剂量米非司酮和左炔诺孕酮用于紧急避孕的临床研究-现代生物医学进展.PDFVIP

Progress in Modern iomedicine 2006 Vol. 6 No. 2 53 小剂量米非司酮和左炔诺孕酮用于紧急避孕的临床研究 1 2 1 步桂英 杨铭越 曹雪莲 ( 1 161041) (2 161041) : 以左炔诺孕酮为参比制剂, 探讨10mg 米非司酮用于紧急避孕的 床效果, 副反应及可接受性: 采用随机 对照性的试验方法,征集 100 例单次无保护性交72 小时内来院就诊的要求紧急避孕的妇女, 随机分配到观察组(n= 50) 和对照组 ( n= 50) , 观察组单次口服10mg 米非司酮, 对照组口服左炔诺孕酮0.75mg, 12 小时后再服左炔诺孕酮0. 75mg, 服药后嘱两组对象 按时随访直至月经复潮, 并观察其避孕效果, 副反应, 对月经的影响及药物的可接受性: 采用 Dixon 方法计算, 两组对象各 有1 例妊娠, 观察组避孕效果达81. 19% , 对照组为81.06% , 统计学上无明显差异, 两组副反应轻, 无任何不良反应发生: 小剂量米非司酮用于紧急避孕与左炔诺孕酮是同样有效的 : 米非司酮; 左炔诺孕酮; 紧急避孕 Clinical study on Administration of Low Dose of Mifepristone and Levonorgestrel in Urgent Postcoital Contraception B U Gui - ying , YAN G M ing - yue, CA O X ue - l ian Dep artment of Gy necology Obstetrics , Fular i Peop le s H osp ital, Qiqihar 161041, Heilong iang , China Dep artment of Gynec ology Obstetrics , Yizhong H osp ital , Qiqihar 161041, Heilong iang , China A STRACT Objective: To investigate t e clinical effects of administration of low dose of Mifepristone( 10mg) in urgent contraception, tak- ing Levonorgestrel as reference preparation. Methods: 100 women, w o ad once ad unprotecting coition and asked for urgent contraception wit in 72 ours after sexual intercourse,were randomly divided into observation group( n= 50) and control group(n= 50) . T e observation group was given only mifepristone( 10mg, orally) ; w ile t e control group was firstly given levonorgestrel(0. 75mg, orally) and t en levonorgestrel(0. 75mg, orally) again in 12 ours. After administration, t e women in t e two groups were told to be followed up statedly until t e next menstrua- tion appears. Meanw ile, birt control effec