病毒在生物医学中的应用.pptx

Application in biomedical research;Over 2000 gene therapy trials;Mainly adenovirus, retrovirus-based;Viral vector based gene delivery;1949, HBV;Cancer Research 1949;什么意思？？？？;关键词： 1、alphavirus M1- 不一定好找，但是单链/双链，DNA/RNA？ 2、Oncolytic virus 3、ZAP？- 提示：zinc-finger antiviral protein;;关键词： 1、alphavirus M1- 天然存在的，来自中国海南，高剂量相对安全；还能引起胶质瘤凋亡(may link to oncolytic virus）;关键词： oncolytic virus原理：;什么是Zap;So easy No need to know exact role of Zap;Antiviral protein From Wikipedia, the free encyclopedia Antiviral proteins?are?proteins?that are induced by human or animal?cells?to interfere with?viral replication. These proteins are isolated to inhibit the?virusfrom replicating in a hosts cells and stop it from spreading to other cells.[1]?The?Pokeweed?antiviral?protein?and the Zinc-Finger antiviral protein are two major antiviral proteins that have undergone several tests for viruses, including?HIV?and?influenza.;Zinc-Finger Antiviral Protein[edit] The?Zinc-Finger?Antiviral Protein (ZAP) is a specific antiviral protein that aids in the destruction of virus particles, specifically the Moloney?murine leukemia virus?(MLV) and the?Sindbis virus?(SIN). ZAP prevents the viral?mRNA?from building up inside the?cell.[5]?ZAP is specifically coded for certain target mRNA. Once a correct viral mRNA is detected, it recruits an RNA?exosome complex?to break down and destroy the viral RNA.[6]?S. Miller and colleagues at theBernhard Nocht Institute for Tropical Medicine?stated that:;The?pokeweed?plant is a common plant that is often used as a?dye; it is also eaten when the plant is young and tender. Studies and experiments have shown that a specific protein, the Pokeweed Antiviral Protein (PAP), could possibly be used as a thereputical use in?T-cell?leukemia,?lymphoma,?Hodgkins lymphoma, and?AIDS. In an experiment posted in the?Journal of Virology, mice immune systems were integrated to mimic that of humans. The mice were then infected with HIV and later given the PAP. The experiment showed that the PA