吡柔比星与柔红霉素分别联合阿糖胞苷治疗急性早幼粒细胞白血病的疗效对比研究.docxVIP

卩比柔比星与柔红霉素分别联合阿糖胞昔治疗急性早幼粒细胞白血病的疗效对比研究 湖南省岳阳市第一人民医院414000 【摘 要】目的：研究毗柔比星与柔红霉素分别联合阿糖胞昔对于急性 早幼粒口血病巩固化疗的疗效。方法：选取我院2013年1月到2016年1月期间 收治的急性早幼粒白血病患者80例为研究对象，将随机分为对照组和试验组， 每组各40例。对照组釆用柔红霉素联合阿糖胞廿方式进行治疗，试验组釆用毗 柔比星联合阿糖胞昔的方式进行治疗，比较两组患者的临床治疗效果，对两组患 者粒细胞集落因子(G?CSF)使用次数、血小板与红细胞输注量进行比较，并比 较两组患者血气指标和不良反应发生率。结果：两组患者治疗后临床治疗总有效 率相比差异不具有显著差异(P0.05),并且两组血气指标差异不具有显著性(P 0.05),但试验组G-CSF使用次数、血小板与红细胞输注量少于对照组，两组 数据差异具有显著性(R0.05),试验组患者不良反应少于对照组，但两组数据 差异不具有显著性(P0.05)o结论：毗柔比星与柔红霉素分别联合阿糖胞昔对 于急性早幼粒白血病巩固化疗的疗效不具有显著差异，但毗柔比星联合阿糖胞廿 治疗的方式对患者心脏损伤较小，值得在临床上推广。 【关键词】卩比柔比星；柔红霉素；阿糖胞昔；急性早幼粒细胞口血病 [Abstract] Objective： To study the effect of the combi nation of the treatment of acute myeloid leukemia with the combination of the treatment of the combi nation of the doxorubicin and the ? Methods： 80 cases of acute leukemia patients admitted in our hospital from January 2013 to January 2016 were randomly divided into control group and experimental group, 40 cases in each group. The control group using daunorubicin and cytarabine for treatment, experimental group were treated with intravesical pirarubicin combined with cytarabine, compared two groups of patients with clinical curative effect of two groups of patients, fall factor gra nu locyte (G-CSF) using times, platelet a nd red cell tra nsfusi on were compared, and comparison of two groups of patients with blood gas index and the incidenee of adverse reaction. Results： two groups of patients after clinical treatment of total efficiency compared to no significant differenee (P gt; 0.05), and the difference between the two groups of blood gas index was not significant (P gt; 0.05), but the test group G-CSF using times, platelets and red blood cell transfusion was less than that of control group, with significant differences between the two groups of data of (P lt; 0.05), test group of patients with adverse reactions than the control group, but the differenee between the two groups of data were not significant(P gt; 0.05). Conclusion： the curative effect of piraru