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17 5 ( ) Vo.l 17 No. 5
2007 9 Journal of Jiangsu Un iversity( M ed icine Ed ition) ep. 2007
MMP9 TIMP1
1 1 1 1 2
万 兵, 郑金旭, 严玉兰 , 黄新建 , 吴建农
( 1. ; 2. , 212001)
[ ] : ( uPA) MMP9/T IMP1:
D 45, 3: (+ ) (+ )
28 HEM asson( ELI A )
MM P9T IMP1: ( 1): ( 1. 7 0. 6) , ( 0. 9 0. 7) ,
( 0. 2 0. 4), , (P 0. 01)( 2): ( 2. 0
0. 8), ( 1. 1 0. 7 ), (P 0. 01)( 3) T IMP1: ( 1 240. 8 90. 3)
pg/m l, ( 1 078. 3 31. 6) pg /m l, ( 1 163. 6 69. 6) pg/m ,l (P
0. 01); , (P 0. 05): ,
TIM P1
[ ] ; ; 9; 1
[ ] R563; R332. 2 [] A [] 1671- 7783( 2007) 05- 0400- 03
Urokinase in the ratmodel of bleomycininduced pulmonary fibrosis and
its impacton the expression ofmatrixmetalloproteinase9 and
tissue inhibitor ofmetalloproteinase1
1 1 1 1 2
WAN B ing , ZH EN G J inx u , YAN Yu lan , H UAN G X inj ian , W U J iannong
( 1. Departm ent of Respiratory D isease; 2. Departm ent of pathology, the Affiliated H ospital of Jiangsu University, Zhenjiang Jiangsu 212001, China)
[Abstract] Objective: To study the effect of urok inase on bleomycininduced pulmonary fibrosis in rats
and its possible mechan ism. Methods: Forty five male D ratsw ere random ly d ivided into three groups:
themodel group, the control group and the urokinase treatment group, in wh ich the ratsw ere intratracheally
instilled w ith bleomycin( 5mg/kg). From the second day after bleomycin challenge, by intraperitoneal in
jection every two days, the urok inase treatment group w as given urok inase ( 27500U /kg),
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