舒血宁合并奥氮平治疗慢性精神分裂症的对照研究.PDFVIP

舒血宁合并奥氮平治疗慢性精神分裂症的对照研究 王鹤秋，顾成宇，任志斌，李冰凌(浙江省立同德医院精神卫生中心，杭州 310012) 摘要：目的 比较舒血宁合并奥氮平与单用奥氮平治疗慢性精神分裂症的疗效。方法 将2009 年 1 月—2011 年 6 月我 院86 例慢性精神分裂症患者分为奥氮平合并用舒血宁治疗组(联合用药组)和单纯服奥氮平治疗组(对照组) ，各43 例。选 用阳性与阴性症状评定量表(PANSS)和精神药物不良反应量表(TESS)评定临床疗效和不良反应。评价治疗前和治疗后第 4 ，8，12 周的病情变化。结果 联合用药组对慢性精神分裂症的有效率为 34.88% ，而对照组的有效率为20.93% ，两组 比较差异有统计学意义(P0.05) 。两组不良反应比较：头晕、嗜睡、心动过速、体重增加方面差异有统计学意义(P0.05) 。 结论 对慢性精神分裂症患者采用奥氮平联合舒血宁治疗比单用奥氮平疗效更好，且不良反应更小。 关键词：舒血宁；奥氮平；慢性精神分裂症 中图分类号：R971.41 文献标志码：B 文章编号：1007-7693(2012)06-0550-05 Comparative Study of Olanzapine Combined with Shuxuening Versus Olanzapine in the Treatment of Chronic Schizophrenia Patients WANG Heqiu, GU Chengyu, REN Zhibin, LI Bingling(Tongde Hospital of Zhejiang Mental Health Center, Hangzhou 310012, China) ABSTRACT: OBJECTIVE To compare the efficacy and safety of olanzapine combined with Shuxuening versus olanzapine in the treatment of chronic schizophrenia inpatients. METHODS Eighty-six patients were recruited in our hospital and randomly assigned to receive olanzapine combined with Shuxuening, or olanzapine for up to 12 weeks. All patients were checked by the scale of PANSS and TESS before treatment and at 4, 8 and 12 weeks during treatment. RESULTS There were statistically significant differences between the trial group and the control group in efficacy and adverse reactions(P0.05). The effective rate of the research group was 34.88%, the control group was 20.93%. The incidence rates of adverse reactions in research group were lower than those in control group in dizziness, drowsiness, tachycardia and weight gain. CONCLUSION Olanzapine combined with Shuxuening may be more efficacious than olanzapine lonely in the treatment of chronic schizophrenia patients, and be much lower in adverse reactions. KEY WORDS: Shuxuening; olanzapine; chronic schizophrenia 目前对精神分裂症主要采用非典型抗精神病 氮平不仅可以改善精神分裂症的阳性症状