以间皮素为靶点的肿瘤特异性核素成像研究进展-肿瘤防治研究.PDF

2018 45 9  Cancer Res Prev Treat,2018,Vol.45,No.9 691 肿瘤防治研究 年第 卷第 期 · · doi:10.3971/j.issn.1000-8578.2018.18.0087 ·综  述· 以间皮素为靶点的肿瘤特异性核素成像 研究进展 1 2 2 1 1 夏雷 ，王旭东 ，杨根 ，朱华 ，杨志 Progress in Mesothelin as Target for Cancer Specific Radionuclide Imaging XIA Lei1 2 2 1 1 , WANG Xudong , YANG Gen , ZHU Hua , YANG Zhi 1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital Institute, Beijing 100142, China; 2. Department of Physics, Peking University, Beijing 100142, China Corresponding Author: ZHU Hua, E-mail: zhuhuananjing@163.com; YANG Zhi, E-mail: pekyz@163.com Abstract: Mesothelin is a special-expressing receptor protein and highly expressed in many cancers, especially in pancreatic cancer(80%-85%). Mesothelin is only expressed on mesothelial cells of the peritoneal, pleural cavities and pericardium in normal tissues. We radiolabeled the anti-mesothelin antibodies with new nuclide, and various cancers can be specifically imaged by the new molecular imaging agents. It’s important for the early diagnosis and therapy tracer of cancers. This review briefly probes mesothelin as a target for the treatment and diagnosis of pancreatic cancer and other tumors, and focuses on the nuclide-labeled anti- mesothelin molecular probes for specific radionuclide imaging. Key words: Mesothelin; Cancer; Molecular imaging; Radionuclide mesothelin, MSLN 摘  要：间皮素（ ）是多种肿瘤表面特异性表达的受体蛋白，特别是在以胰腺癌 80%~85% （ ）为首的多种实体肿瘤中高表达，而在正常组织中间皮素的表达仅局限于胸膜、心包膜和腹膜 MSLN 中。通过新型核素标记抗 抗体，可以对多种肿瘤进行特异性成像，对肿瘤早期诊断及预后评价起到 重要的作用。本综述以间皮素为靶点，阐述与该靶点相关的胰腺癌等相关肿瘤间皮素靶点诊疗的重要进 展，并重点阐述了核素标记的具有MSLN特异