哺乳动物性早熟相关基因的研究进展-遗传.PDF

HEREDITAS (Beijing) 2009 1 , 31(1): 13―28 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2009.00013 哺乳动物性早熟相关基因的研究进展 1 2 1 3 2 储明星 , 冯涛 , 狄冉 , 张宝云 , 张英杰 1. , , 100193; 2. , 730070; 3. , 400030 人类的性早熟是一种病理状态, 而在动物上, 性早熟可能是一个在生产上具有价值的数量性状。一些物 种在进化过程中形成了性早熟的特性并能在群体中稳定遗传。性早熟在很大程度上与遗传密切相关, 是一个由 多基因决定的复杂性状。文章主要介绍了KiSS-1 基因、GPR54 基因、LHR 基因、FSHR 基因、CYP 基因家族、 ER 基因、TGFα基因、IGF- Ⅰ基因、GNAS1 基因、HSD3B2 基因、SHBG 基因、VDR 基因等与哺乳动物性早熟 的关系。 性早熟; 初情期; 基因; 生殖; 调控 Advances on related genes with sexual precocity in mammals 1 2 1 3 2 CHU Ming-Xing , FENG Tao , DI Ran , ZHANG Bao-Yun , ZHANG Ying-Jie 1. Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193, China; 2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China; 3. Bioengineering College, Chongqing University, Chongqing 400030, China Abstract: In mammals and humans, reproductive capacity is attained at puberty as the end-point of a complex series of developmental and neuroendocrine events that lead to true sexual maturity. As for humans, sexual precocity looks like a pathologic status. While for some animals, sexual precocity may be a valuable quantitative character. For some species, the character of sexual precocity was developed in the evolutionary process and stably transmitted to future generations. Sexual precocity is a complex character determined by polygenes. This review introduced the association between KiSS-1, GPR54, LHR , FSHR, CYP, E