研讨会课件---分子光谱用于药品现状和快速品控的最新进展.pdfVIP

分子光谱用于药品现场和快速品控的最新进展 产品经理：Kimi Gao/高海川 联系电话 电子邮箱：kimi.gao@ Proprietary Confidential The world leader in serving science 技术篇-分子振动光谱基本原理 • Molecules are made up of atoms held together by chemical bonds. These bonds are not rigid – they vibrate/分子是由原子通过化学键结合在一起形成的。这些键不是刚性 的，而是不断振动的 • The bonds vibrate at different frequencies (wavelengths) depending on the atoms connected by the bond, the type of bond and bond strength, and neighboring atoms and bonds./化学键的振动频率取决于其两端的原子、键的类型、键的强度、相邻的原 子和化学键 • Vibrational spectroscopy characterizes materials based on measured patterns of vibrational frequencies/通过测量振动频率，分子光谱可以表征物质的结构 2 Proprietary Confidential 技术篇-分子振动光谱基本原理 • Charged Balls and Electromagnetic Wave/ 带电荷的小球和电磁波 • Atoms interact with electric field of EM wave, stretching or compressing bond/原子 与电磁波的电场相互作用，拉伸或者压缩化学键 Electric Field + + + - - - Magnetic Field  Resonance at frequency (wavelength) that matches molecular characteristics/ 当电磁波的频率与分子振动特征频率相同时，发生共振  Light intensity decreased from increase in molecular vibrations/光的强 度随着分子振动加强而衰减 3 Proprietary Confidential 技术篇-分子振动光谱基本原理 • Ionic bonds/ 离子键 • Covalent bonds/共价键 • Attraction of charges causes • Sharing of charges causes molecules to behave like molecules to behave like a spring/ magnets/组成分子的原子间抢夺 组成分子的原子间共享电子，类似 电子，类似磁铁 弹簧 • Invisible to IR and Raman/无信 • Observable with IR and Raman/有 号 信号