PFOS Lecture 5 Disorders of Lipid Metabolism英文文献资料.pdfVIP

PFOS1 Disorders of lipid metabolism: (i)obesity, (ii) dyslipidemia, (iii) lipid storage disease, and (iv) inborn errors of steroid biosynthesis NG Tzi Bun PFOS1-LE058 2013-2014 (Materials shaded and words in grey can be ignored, only included for reference. Important information in bold face.) 1 I.OBESITY: Assessment methods, causes, consequences and treatments. (Note association between Obesity and type 2 diabetes) 2 Definition of Obesity (肥胖症 ) weight (kg) Body mass index (BMI) = 2 2 height (m ) i. Overweight = BMI of 25 - 30 kg/m2 = grade I obesity ii. Clinical or grade II Obesity = BMI 30 kg/m2 iii. Morbid or grade III obesity = BMI 40 kg/m2 (a) severe obesity 40 kg/m2 (b) morbid obesity 40-50 kg/m2 (c) super obesity 50 kg/m2 Morbid 病態 3 Other methods to assess obesity (1) Waist circumference (men 40 inches, women 35 inches) (2) Waist circumference to hip circumference ratio (=waist: hip ratio) (3) Use caliper to gauge skin fold thickness to biceps + triceps + subscapular + abdomen 4 Medical complications associated with obesity • LDL-cholesterol and triglyceride, HDL- cholesterol in blood • Hypertension (= HT). risk for heart failure, kidney failure for untreated HT • Atherosclerosis of Coronary artery and cardiomyopathy • Stro