大鼠非酒精性脂肪肝造模方法的改进.docVIP

大鼠非酒精性脂肪肝造模方法的改进 ? 世界华人消化杂志 2007年4月18日; 1511: 1219-1224wcjd@wjgnet ISSN 1009-3079 CN 14-1260/R BASIC RESEARCH 基础研究 大鼠非酒精性脂肪肝造模方法的改进 王 倩, 管小琴 王倩, 管小琴, 重庆医科大学病理教研室 重庆市 400016 ■ B 249.63 ± 34.25, 241.88 ± 20.75 vs 275.38 ± 6.59, 背景资料 王倩, 医学硕士, 主要从事肝胆病理研究. 近年来, 由于生活 P 0.05, but there was no marked difference 通讯作者: 管小琴, 400016, 重庆市渝中区医学院路1号, 重庆医 水平的提高, 饮食 科大学病理教研室. guanxiaoqin2003@//0. between group A and C P 0.05. In the fifth 结构的变化, 我国 收稿日期: 2006-12-27接受日期: 2007-01-20 week, light microscopy showed a great number 由高脂血症、高 血压、肥胖、糖 of fatty vacuoles in liver cells, and electron mi- 尿病和药物损害 croscopy confirmed the presence of abundant 等引起的非酒精 Improvement of induction lipid droplets. Different degrees of hepatic fatty 性脂肪肝发病率 method of non-alcoholic fatty degeneration +~+++ was observed in group C 呈上升趋势, 现已 liver model in rats 成为危害人类健 H 13.36, P 0.0003, but not in group A and B康的三大肝病之 The serum levels of TG, TC, ALT and MDA were 一 , 并 与 失 代 偿 Qian Wang, Xiao-Qin Guan markedly higher in group C than those in group 期肝硬化、肝功 A and B TG: 1.28 ± 0.61 mmol/L vs 0.72 ± 0.12, 能衰竭、原发性 肝癌的发生密切 Qian Wang, Xiao-Qin Guan, Department of Pathology, 0.76 ± 0.04 mmol/L; TC: 12.78 ± 1.47 mmol/L vs 相关. 非酒精性脂 Chongqing University of Medical Sciences, Chongqing 1.71 ± 0.03, 2.31 ± 0.49 mmol/L; ALT: 1518.64 ± 肪肝病是遗传-环 400016, China 186.04 nkat/L vs 1181.57 ± 37.84, 1262.92 ± 159.20 境-代谢应激相关 Correspondence to: Xiao-Qin Guan, Department of Pa- thology, Chongqing University of Medical Sciences, 1 Yu- nkat/L; MDA: 13.40 ± 4.24 μmol/L vs 5.89 ± 1.05, 性疾病, 与胰岛素 zhong Road, Yuzhong District, Chongqing 400016, 抵抗及其相关的 7.23 ± 1.15 μmol/L; all P 0.05, but the activity China. guanxiaoqin2003@//. 代谢综合征和遗 of SOD was lower in group C 5.21 ± 0.81 nkat/ 2006-12-27 2007-01-20 Received: Accepted: 传易感性有关mL vs 11.91 ± 2.69, 11.19 ± 0.78 nkat/mL, P 0.05. There were no notable differences between group A and B P 0.05. The tissue contents Abstract of TG and TC were drama