色氨酸羟化酶A218C基因多态性与精神分裂症-神经疾病与精神卫生.PDF

神经疾病与精神卫生2017年第17卷第12期 ·学术交流· 色氨酸羟化酶A218C基因多态性与精神分裂症遗传 关联性研究的Meta分析 杨汝阳 仇剑崟 谢斌 【摘要】 目的 综合分析色氨酸羟化酶（TPH）A218C 基因多态性与精神分裂症遗传易感性的关 系。方法 检索国内外数据库中有关精神分裂症与A218C 相关性研究的文献，按照纳入与排除标准进 行筛选，获得2017 年5 月份以前公开发表的病例对照研究的资料，评价文献质量后采用Stata 14.0 软件对 A218C 多态性做Meta 分析。结果 共纳入11 个病例对照研究，包括3 419 例精神分裂症患者和4 048 例 对照。Meta 分析显示TPH 218A 等位基因能够增加精神分裂症的易感性，但存在种族差异，携带A 等位基 因的白种人群罹患精神分裂症的风险更高。结论 TPH A218C 基因多态性与精神分裂症相关，可能是发 生该病的危险因素。 【关键词】　精神分裂症； 色氨酸羟化酶； 单核苷酸多态性； Meta 分析； A218C - doi ：10.3969/j.issn.1009 6574.2017.12.010 Genetic correlation research between tryptophan hydroxylase gene A218C polymorphism and - - schizophrenia ： a Meta analysis　YANG Ru yang ， QIU Jian yin ， XIE Bin. Shanghai Mental Health Center ， Shanghai Jiao Tong University School of Medicine ， Shanghai 200030 ， China 【Abstract 】 Objective To make a comprehensive analysis of the association between tryptophan hydroxylase （TPH） gene A218C polymorphism and the susceptibility to schizophrenia. Methods Retrieval of literature on the relevance of schizophrenia and A218C in the domestic and foreign databases was conducted. Case-control studies published before May 2017 were obtained by screening in accordance with the inclusion and exclusion criteria. After evaluating the quality of literature ， Stata 14.0 software was used to do Meta analysis on A218C polymorphism. Results A total of 11 case-control studies were incorporated ， including 3 419 cases of schizophrenia and 4 048 controls. Meta analysis showed that TPH 218A allele can increase the susceptibility to schizophrenia ， but with racial differences. The white people carrying A allele had a higher risk of suffering from schizophrenia. Conclusions TPH A218C gene polymorphism is associated with