Quantitative detection of DNA methylation states in minute amounts of DNA from body fluids 微量体液dna甲基化状态的定量检测.pdfVIP
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YMETH 2578 No. of Pages 6, Model 5G
ARTICLE IN PRESS
8 April 2010
Methods xxx (2010) xxx–xxx
1
Contents lists available at ScienceDirect
Methods
journal homepage: www.else /locate/ymeth
2 Review Article
3 Quantitative detection of DNA methylation states in minute amounts of DNA
4 from body fluids F
5 Anupam Paliwal, Thomas Vaissière, Zdenko Herceg * O
6 Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008 Lyon, France
7 O
a r t i c l e i n f o a b s t r a c t
9
2 2
10 Article history: Quantitative and reliable estimation of DNA methylation levels for multiple genomic regions pose a 23
R
11 Accepted 28 March 2010 major challenge where starting DNA is available in very low quantity. Here we review major advances 24
12 Available online xxxx in the development of techniques for quantitative detection of DNA methylation in minute amount of 25
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