重性抑郁障碍发病的表观遗传调控假说.pdf

HEREDITAS (Beijing) 2008 6 , 30(6): 665―670 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2008.00665 1, 2 1 2 党永辉 , 李生斌 , 孙中生 1. , 710061; 2. , 101300 : 表观遗传学是研究主要受控于 DNA 甲基化、染色质结构变化的可遗传和逆转的基因组功能的调控。近 年来, 越来越多的证据表明表观遗传因素在精神分裂症、双相障碍、药物成瘾等重性精神障碍的发病中扮演着 重要角色。文章综述了表观遗传现象的分子机制, 介绍了表观遗传修饰与复杂性疾病的关系, 并在此基础上对 重性抑郁障碍(Major depressive disorder, MDD)发病的表观遗传调控假说及最新研究进展进行了总结。 : 抑郁症; 表观遗传学; DNA 甲基化; 组蛋白修饰 The role of epigenetic regulation in etiology of major depressive disorder 1,2 1 2 DANG Yong-Hui , LI Sheng-Bin , SUN Zhong-Sheng 1. Department of Forensic Sciences , College of Medicine, Xi ’an Jiaotong University, Xi ’an 710061, China; 2. Behavioral Genetics Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 101300, China Abstract: Epigenetics refers to the heritable, but reversible, regulation of various biological functions mediated principally through changes in DNA methylation and chromatin structure derived from histone modification. Recent research indicated that epigenetic mechanisms may play vital role in etiology of major psychosis, such as schizophrenia, bipolar disorder and drug addiction. With brief introduction of epigenetic molecular mechanisms and relevance of epigenetics to human com- mom diseases, this review focuses on epigenetic hypothesis and some supporting evidence which are recently emerged in major depressive disorder (MDD). Keywords: depression; epigenetics; DNA methylation; histone modification [1] , , , , DNA (Epimutation), (Genomic imprinting),