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中国组织工程研究与临床康复第7,卷舅6期2007—02—11出版
JournalofClinicalRehabilitativeTissueEngineeringResearch
February11,2007
VoL{{fNoi6
临床医学
脊髓型颈椎病患者颈椎问盘白细胞介素6和月中瘤坏死因子OL水平与
日本骨科学会颈髓功能评分的相关性★
周思启1,陈惠德1,汤健2,杨庆国2,吴毅文
Contentsofinterleukin-6andtumornecrosisfactor-alphainthecervicalintervertebraldisksofpatientswithcervicalspondyloticmyelopathyassociatedwiththeJapaneseAssociationScoreforcervicalspinalcordfunction
Abstract
Med'Dep:端篙端
Oiatedrtho印eH0sdics。,itF
Medical
Anhui
University,Hefei230032,AnhuiProvince.C:hina
ZhouSi—qi★Studyingformaster’sdegreeDepartmentofSpodsMedicine,AffiliatedAnhui
First
Orthopaedic删of
AIM:Tomeasurethecontentsofinterleukin一6(IL一6)andtumornecrosisfactor—d(TNF.or.)inthecervicaIintervertebraIdiskofpatientswithcervicaspondyloticmyelopathy(CSM),analyzetherelationshipofIL一6andTNF.dcontentswiththeJapaneseOrthopaedicAssociation(JOA)score,studytheroleofImmunereactioninthepathogenesisofCSM.
METHODS:Twenty—seveninpatientswithCSMwereenrolledascasegroup.sixteenpatientswereenrolledinIhesurgicaloperationpatientswithtraumaticcervicainjuryse~edascentreIgroup.whohadnoCSMdiseasehistoryinthe
DepartmentofOrthopaedics,FirstAffiliatedHospital,AnhuiMedicalUniversityfromNovember1Or.,2005toJune30th.2006.Cervicalintervertebraldiskswereobtainedfrompatientsofthetwogroupsundergoinganteriorsurgery.ThecontentsofIL-6andTNF一仅inalIspecimensofthetwogroupsweremeasuredwithradioimmunoassayfRIAlmethodThe27CSMsufferersweredividedinto
Hospital,
MedicaIHefeiUniversity
230032AnhujProvince,C:hina
twogroupsaccordingtotheJOAscore:moderateand
severe
groupscored
zhousq999@sina
com
fromO一12points,totally20patients,andmildgroupscoredfrom13~17points.totally7patients.
RESIJ】LTS:Totally43caseswereinvolvedintheresultanalysis.①ThecontentsofIL-6andTNF.仅indiskofCSMsufferersIncreasedsignificantlycomparedwiththecentrel
Received:2006-07—12Accepted:2006-08-18
group【IL一6:(34.521±18.592),(15.041-+6.562)ng/L;TNF.d:
severe
(6.071±1.912),(3。143_+0.630)pmol/L;尸<0。011.②The
groupofJOA
scoreofTNF.0【increasedsignificantlyinmoderateand
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