脊髓型颈椎病患者颈椎间盘白细胞介素6和肿瘤坏死因子α水平与日.docVIP

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脊髓型颈椎病患者颈椎间盘白细胞介素6和肿瘤坏死因子α水平与日.doc

中国组织工程研究与临床康复第7,卷舅6期2007—02—11出版 JournalofClinicalRehabilitativeTissueEngineeringResearch February11,2007 VoL{{fNoi6 临床医学 脊髓型颈椎病患者颈椎问盘白细胞介素6和月中瘤坏死因子OL水平与 日本骨科学会颈髓功能评分的相关性★ 周思启1,陈惠德1,汤健2,杨庆国2,吴毅文 Contentsofinterleukin-6andtumornecrosisfactor-alphainthecervicalintervertebraldisksofpatientswithcervicalspondyloticmyelopathyassociatedwiththeJapaneseAssociationScoreforcervicalspinalcordfunction Abstract Med'Dep:端篙端 Oiatedrtho印eH0sdics。,itF Medical Anhui University,Hefei230032,AnhuiProvince.C:hina ZhouSi—qi★Studyingformaster’sdegreeDepartmentofSpodsMedicine,AffiliatedAnhui First Orthopaedic删of AIM:Tomeasurethecontentsofinterleukin一6(IL一6)andtumornecrosisfactor—d(TNF.or.)inthecervicaIintervertebraIdiskofpatientswithcervicaspondyloticmyelopathy(CSM),analyzetherelationshipofIL一6andTNF.dcontentswiththeJapaneseOrthopaedicAssociation(JOA)score,studytheroleofImmunereactioninthepathogenesisofCSM. METHODS:Twenty—seveninpatientswithCSMwereenrolledascasegroup.sixteenpatientswereenrolledinIhesurgicaloperationpatientswithtraumaticcervicainjuryse~edascentreIgroup.whohadnoCSMdiseasehistoryinthe DepartmentofOrthopaedics,FirstAffiliatedHospital,AnhuiMedicalUniversityfromNovember1Or.,2005toJune30th.2006.Cervicalintervertebraldiskswereobtainedfrompatientsofthetwogroupsundergoinganteriorsurgery.ThecontentsofIL-6andTNF一仅inalIspecimensofthetwogroupsweremeasuredwithradioimmunoassayfRIAlmethodThe27CSMsufferersweredividedinto Hospital, MedicaIHefeiUniversity 230032AnhujProvince,C:hina twogroupsaccordingtotheJOAscore:moderateand severe groupscored zhousq999@sina com fromO一12points,totally20patients,andmildgroupscoredfrom13~17points.totally7patients. RESIJ】LTS:Totally43caseswereinvolvedintheresultanalysis.①ThecontentsofIL-6andTNF.仅indiskofCSMsufferersIncreasedsignificantlycomparedwiththecentrel Received:2006-07—12Accepted:2006-08-18 group【IL一6:(34.521±18.592),(15.041-+6.562)ng/L;TNF.d: severe (6.071±1.912),(3。143_+0.630)pmol/L;尸<0。011.②The groupofJOA scoreofTNF.0【increasedsignificantlyinmoderateand

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