MAPK信号转导通路对炎症反应的调控.docVIP

丝裂原活化蛋白激酶(mitogen-activated proteink inase,MAPK是介导细胞反应的重要信号系统,普遍存在于多种生物,包括酵母和哺乳动物细胞。自从1991年Sturgill 及其同事在哺乳动物细胞鉴定出细胞 外信号调节激酶(extracellular-signal re gulatedprotein kinase,E RK,MAPK 信号转导通路的研究取得了迅猛发展[1,2]。除ERK 外,还发现和克隆了c-Jun 氨基未端激酶(c-Jun amino-terminal kinase,JNK/ 267 综述 MAPK 信号转导通路对炎症反应的调控 姜勇 , 龚小卫 (第一军医大学病理生理教研室暨全军休克微循环重点实验室,广州510515 摘要: 丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK是生物体内重要的信号转导系统之一,参与 介导生长、发育、分裂、分化、死亡以及细胞间的功能同步等多种细胞过程。在哺乳动物细胞中已发现和克隆了ERK JNK/S APK 、p38/RK 、ERK5/B MK1四个MAPK 亚族。这些MAPK 能被多种炎性刺激所激活,并对炎症的发生、发展起重要调控作用。研究感染和炎症反应过程中这些MAPK 被激活的机制及其生物学效应,探讨MAPK 特异性抑制剂的药理学作用及分子基础,对于感染的防治及炎症反应的控制有着广泛的应用前景。关键词:丝裂原活化蛋白激酶;信号转导;炎症反应学科分类号:Q288 Regulation of inflammatory responses by MAPK signal transduction pathways JIANG Yong ,GONG Xiao-Wei (De parment o f Pathophysiology and Key Laboratoryr Shock and Microcirculation o f PLA , First Military Medical University ,Guangzhou 510515 Abstract: Mitogen-activated protein kinase (MAPK,which is one of the important signal transductionsys te ms in organisms,is involved in many cellular processes,such as cell growth,development,division,differentia tion,death and coordination of cellular func tions,and etc.Four subfamilies of MAP kinases,i. e.ERK, JNK/SAPK,p38/RK and E RK5/B MK1,have been identified and cloned in mammalia m cells.TheseMAP kinas es are activated by many proinfla mmatory stimuli and play an important role in the pathogenesis anddevelop ment of inflam mation.In this article recent advances in the study of the mechanisms underlyingactivation of MAPKs in infection and inflammation and the molecular basis of specific inhibitors for MAPKs arerevie wed,in special reference with the perspective prevention and treatment of inflam mation by these kinases.Keywords:mitogen-activated protein kinase;signal transduction;inflammatory responses 生理学报,Aug.2000,52(4:267~271Acta Physiologica Sinica Recei ved 1999-11-01Accep ted 2000-03-30 This stud y we s upp orted b y Nati onal Science Fu nd for Dis tin gui shed You ng Sch olars