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2009,42(1):261-266
Scientia Agricultura Sinica doi: 10.3864/j.issn.0578-1752.2009.01.033
210095
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Effects of Flaxseed Lignans on the Growth of Skeletal Muscle of
Male Rats and Its Possible Mechanism
ZHOU Wei, WANG Guo-jie, HAN Zheng-kang
(Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture of China, Nanjing Agricultural University,
Nanjing 210095)
Abstract: Objective To determine whether flaxseed lignans could affect the growth of skeletal muscle in male animals and
its possible mechanisms. Method The effect of the flaxseed lignans on skeletal muscle in male rats were determined in vivo.
Daidzein (5 mg·kg-1) and flaxseed lignans (50 mg·kg-1) were added into the basal diets, respectively, and the concentrations of the
serum lignans and daidzein were measured by HPLC, serum growth hormone and testosterone (T) levels were analyzed by RIA, and
the expression of estrogen receptor β (ERβ) in the soleus muscle and hypothalamus were determined by RT-PCR.Result Flaxseed
lignans and daidzein significantly improved the feed efficiency and increased the total weight gain of the femoral muscle in male rats.
The rate of RNA to DNA in muscles and serum T levels were remarkably increased, while the urea nitrogen concentrations were
significantly decreased by daidzein and flaxseed lignan and/or its metabolites. Meanwhile the expression of estrogen receptorβ (ERβ)
in soleus muscle and hypothalamus were both upgraded by the two phytoestrogens. Conclusion Flaxseed lignan promoted the
growth of male rats, and it may regulate serum T levels through binding to ER β in hypothalamus. In turn, it depressed the catabolism
of protein and
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