传染性海绵状脑病的诊断进展和存在的问题.pdf

Progress in Modern Biomedicine 2006 Vol. 6 No. 7 # 57 # X 传染性海绵状脑病的诊断进展和存在的问题 1, 2 1 1 1 吴长德 赵德明 杨建民 周向梅 ( 1 北京100094 2 沈阳110161 : 传染性海绵状脑病是由朊病毒引起的人 多种哺乳动物以神经退行性变化为主要特征的一种慢性致死性传染病引 起这类疾病的病原因子是一种编码宿主蛋白的PrPC 转变为异常的PrPSC 沉积在大脑, 导致传染性海绵状脑病的发生本文从临 床症状识别组织病理学诊断致病性朊蛋白检测生物学测定以及毒株鉴定等几 个方面作 一回顾 总结, 为揭示朊病毒疾病致 病机理 诊断研究提供借鉴 : 传染性海绵状脑病; 诊断; 进展 : S855 : A Progress and problems in the diagnostics of transmissible spongiform encephalopathy 1, 2 1 1 1 WU Chang - de , ZHA O De - ming , YANG Jian - min , ZHOU Xiang - mei 1 National Animal Transmissible Sp ong i orm E ncep halop athy L aboratory , College o Veterinary Medicine, China Agricultural Univ ersity , B eji ing 100094, China 2 Colleg e o A nimal Science and Veterinary Medicine, Shenyang Ag ricultural Univ ersity , Liaoning 110161, China ABSTRACT The transmissible spon iform encephalopathies (TSEs) , are a roup of chronic fatal neurode enerative diseases in humans and in a variety of mammalian animals. These prion diseases are associated with the deposition of PrPSc, a disease- specific isoform of the host - encoded cellular prion protein ( PrPC) , which accumulates in the brain affected with most forms of TSE. This article reviews and summarizes recent pro ress in the areas of the reco nition of characteristic clinical si ns, the dia noses of histopatholo y, the detection of di