组会文献汇报样板.pptVIP

Preparation, Characterization, Cytotoxicity, and Genotoxicity Evaluations of Thiolated- and S?Nitrosated Superparamagnetic IronOxide Nanoparticles: Implications for Cancer Treatment Amedea B. Seabra,*,?Tatiane Pasquoto,?Ana Carolina F. Ferrarini,?Marconi da Cruz Santos,?Paula S. Haddad,?and Renata de Lima § Introduction Result and discusion Characterization of Thiolated Fe3O4 Nanoparticles. The results revealed that thiolated nanoparticles have low toxicity, whereas S-nitroso nanoparticles were observed to cause cytotoxic and genotoxic e?ects in di?erent cell lines. Furthermore, the magnetic property of the S-nitrosated nanoparticles was used as a tool to generate a local cytotoxic e?ect directly at the target site of application. S-Nitrosated nanoparticles appear to constitute a potentially promising agent for the treatment of cancer and prevention of the metastatic cascade; therefore, further studies are required to clearly understand the complex and wide-ranging roles of NO to facilitate its therapeutic usage. Conclusion